Your Navigation:PCAR > Abstract
Search pcar
检索项:
检索词:
Abstract
Pharmaceutical Care and Research: 2017; 17(6):401-404
DOI: 10.5428/pcar20170601
Advances in the mechanisms of butylphthalide and its derivatives for treatment of stroke
1. XUE ChaoJun(Department of Pharmacy,People’s Hospital of Hebei Province,Shijiazhuang 050000,China 397953392@qq.com)
2. JIN HuiXin(Department of Pharmacy,People’s Hospital of Hebei Province,Shijiazhuang 050000,China )
3. ZHANG XuDong(Department of Pharmacy,People’s Hospital of Hebei Province,Shijiazhuang 050000,China xchjasd@126.com)
ABSTRACT  Butylphthalide,the first class new cardiovascular drug with independent intellectual property rights in China,is used for the treatment of ischemic stroke.In spite of its sound therapeutic effects,it is of poor water solubility,thus making its derivatives a hot research spot.The paper gives a comprehensive review on the mechanisms of butylphthalide and its derivatives in the treatment of stroke from the perspectives of anti-platelet aggregation and formation of anti-thrombosis,mitochondrial protection,neuronal cell protection,anti-oxidative stress and the promotion of nerve regeneration.
Welcome to PCAR! You are the number 335 reader of this article!
Please cite this article as:
XUE ChaoJun,JIN HuiXin,ZHANG XuDong,. Advances in the mechanisms of butylphthalide and its derivatives for treatment of stroke[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2017; 17(6): 401-404.
References:
1. DIAO XingXing,DENG Pan,XIE Cen,et al.Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation[J].Drug Metab Dispos,2013,41(2):430-444.
2. DIAO XingXing,ZHONG Kan,LI XiuLi,et al.Isomer-selective distribution of 3-n-butylphthalide (NBP) hydroxylated metabolites,3-hydroxy-NBP and 10-hydroxy-NBP,across the rat blood-brain barrier[J].Acta Pharmacol Sin,2015,36(12):1520-1527.
3. PENG Ying,ZENG XianKe,FENG YiPu,et al.Antiplatelet and antithrombotic activity of L-3-n-butylphthalide in rats[J].J Cardiovasc Pharmacol,2004,43(6):876-881.
4. LAN ZuJian,XU XiaoYu,XU WenKai,et al.Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent[J].Drug Des Devel Ther,2015,9:3377-3391.
5. WANG XiaoLi,WANG LinNa,LI TingTing,et al.Novel hybrids of optically active ring-opened 3-n-butylphthalide derivative and isosorbide as potential anti-ischemic stroke agents[J].J Med Chem,2013,56(7):3078-3089.
6. YIN Wei,LAN Li,HUANG ZhangJian,et al.Discovery of a ring-opened derivative of 3-n-butylphthalide bearing NO/H2S-donating moieties as a potential anti-ischemic stroke agent[J].Eur J Med Chem,2016,115:369-380.
7. WANG XiaoLi,WANG LinNa,HUANG ZhangJian,et al.Synthesis and biological evaluation of nitric oxide releasing derivatives of 6-amino-3-n-butylphthalide as potential antiplatelet agents[J].Bioorg Med Chem Lett,2013,23(7):1985-1988.
8. WANG XiaoLi,WANG LinNa,SHENG Xiao,et al.Design,synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents[J].Org Biomol Chem,2014,12(31):5995-6004.
9. Abdoulaye I A,GUO YiJing.A review of recent advances in neuroprotective potential of 3-n-butylphthalide and its derivatives[J].Biomed Res Int,2016,2016:ID 5012341.
10. CHANG Qing,WANG XiaoLiang.Effects of chiral 3-n-butylphthalide on apoptosis induced by transient focal cerebral ischemia in rats[J].Acta Pharmacol Sin,2003,24(8):796-804.
11. LI JiMei,LI Yin,Ogle M,et al.DL-3-n-butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway[J].Brain Res,2010,1359:216-226.
12. ZHAO Qian,ZHANG Chao,WANG XuLiang,et al.(S)-ZJM-289,a nitric oxide-releasing derivative of 3-n-butylphthalide,protects against ischemic neuronal injury by attenuating mitochondrial dysfunction and associated cell death[J].Neurochem Int,2012,60(2):134-144.
13. Schenk R L,Strasser A,Dewson G.BCL-2: Long and winding path from discovery to therapeutic target[J].Biochem Biophys Res Commun,2017,482(3):459-469.
14. Ashkenazi A,Fairbrother W J,Leverson J D,et al.From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors[J].Nat Rev Drug Discov,2017,16(4):273-284.
15. YANG WeiHong,LI Ling,HUANG RuXun,et al.Hypoxia inducible factor-1α mediates protection of DL-3-n-butylphthalide in brain microvascular endothelial cells against oxygen glucose deprivation-induced injury[J].Neural Regen Res,2012,7(12):948-954.
16. SUN Bo,FENG MeiJiang,TIAN XiangYang,et al.DL-3-n-Butylphthalide protects rat bone marrow stem cells against hydrogen peroxide-induced cell death through antioxidation and activation of PI3K-Akt pathway[J].Neurosci Lett,2012,516(2):247-252.
17. ZHANG Ping,GUO ZhenFang,XU YuMing,et al.N-Butylphthalide (NBP) ameliorated cerebral ischemia reperfusion-induced brain injury via HGF-regulated TLR4/NF-κB signaling pathway[J].Biomed Pharmacother,2016,83:658-666.
18. ZHAO WanHong,LUO Chao,WANG Jue,et al.3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia[J].Neural Regen Res,2014,9(7):719-726.
19. YANG LiChao,LI Jiang,XU ShaoFeng,et al.L-3-n-butylphthalide promotes neurogenesis and neuroplasticity in cerebral ischemic rats[J].CNS Neurosci Ther,2015,21(9):733-741.
20. Bederson J B,Pitts L H,Tsuji M,et al.Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination[J].Stroke,1986,17(3):472-476.
21. Lesage F,Lazdunski M.Molecular and functional properties of two-pore-domain potassium channels[J].Am J Physiol Renal Physiol,2000,279(5):F793-F801.
22. LI ZhengBin,ZHANG HaiXia,LI LiaoLiao,et al.Enhanced expressions of arachidonic acid-sensitive tandem-pore domain potassium channels in rat experimental acute cerebral ischemia[J].Biochem Biophys Res Commun,2005,327(4):1163-1169.
23. XU XiangHua,PAN YaPing,WANG XiaoLiang.Alterations in the expression of lipid and mechano-gated two-pore domain potassium channel genes in rat brain following chronic cerebral ischemia[J].Mol Brain Res,2004,120(2):205-209.
24. ZHANG Man,YIN HuaJing,WANG WeiPing,et al.Over-expressed human TREK-1 inhibits CHO cell proliferation via inhibiting PKA and p38 MAPK pathways and subsequently inducing G1 arrest[J].Acta Pharmacol Sin,2016,37(9):1190-1198.
25. XI GuangJun,ZHANG XiangRong,ZHANG Ling,et al.Fluoxetine attenuates the inhibitory effect of glucocorticoid hormones on neurogenesis in vitro via a two-pore domain potassium channel,TREK-1[J].Psychopharmacology (Berl),2011,214(3):747-759.
26. WANG MingHuan,SONG JingJiao,XIAO Wu,et al.Changes in lipid-sensitive two-pore domain potassium channel TREK-1 expression and its involvement in astrogliosis following cerebral ischemia in rats[J].J Mol Neurosci,2012,46(2):384-392.
27. Hughes S,Magnay J,Foreman M,et al.Expression of the mechanosensitive 2PK+ channel TREK-1 in human osteoblasts[J].J Cell Physiol,2006,206(3):738-748.
28. JI XinCai,ZHAO WanHong,CAO DongXu,et al.Novel neuroprotectant chiral 3-n-butylphthalide inhibits tandem-pore-domain potassium channel TREK-1[J].Acta Pharmacol Sin,2011,32(2):182-187.
《药学服务与研究》杂志社 All Rights Reserved 网站备案号:鲁B2-20061008
·地址:上海市杨浦区长海路168号18号楼东三楼 邮政编码:200433
·联系电话(传真):86-21-65519829, 021-31162330
·电子邮件:PharmCR@vip.163.com
·技术支持:中国康网
管理员入口