Your Navigation:PCAR > Abstract
Search pcar
Pharmaceutical Care and Research: 2017; 17(6):415-418
DOI: 10.5428/pcar20170605
Effects of α-thioctic acid on the promotion of bone formation in elderly men with type 2 diabetes mellitus
1. SUN Fei(Department of Endocrinology,Gongli Hospital of Shanghai Pudong New Area,Shanghai 200135,China
2. MA JunHua(Department of Endocrinology,Gongli Hospital of Shanghai Pudong New Area,Shanghai 200135,China )
3. WANG JingNan(Department of Endocrinology,Gongli Hospital of Shanghai Pudong New Area,Shanghai 200135,China )
4. GU MingJun(Department of Endocrinology,Gongli Hospital of Shanghai Pudong New Area,Shanghai 200135,China
ABSTRACT  Objective: To observe the effects of α-thioctic acid on bone metabolism in elderly men with type 2 diabetes mellitus.Methods: Totally,50 elderly men with type 2 diabetes mellitus were randomly assigned to the α-thioctic acid group (or the treatment group) and the non α-thioctic acid group (or the control group),each consisting of 25 patients.The patients in the treatment group were treated with α-thioctic acid for 14 days.General data of the patient conditions were collected before medication.Then,detections were made in bone formation indexes,including bone alkaline phosphatase,osteocalcin,total type Ⅰ collagen end amino extended peptide (PINP),and bone resorption index,including β- type Ⅰ collagen end-carboxy peptide degradation products.Three months after treatment,detection of the changes in the indexes of bone formation and bone resorption was made in the patients of the 2 groups,and statistical analyses were performed accordingly.Results: Before treatment,there were no statistical differences in the indexes of bone metabolism,when comparisons were made between the patients of the 2 groups.However,following treatment,the levels of PINP in the patients of the treatment group elevated,as compared with those before treatment (P<0.05),and statistical significance could also be noted,when compared with those of the control group (P<0.05).Conclusion: α-Thioctic acid could elevate PINP level in the elderly men with type 2 diabetes and consequently promote bone formation.
Welcome to PCAR! You are the number 53 reader of this article!
Please cite this article as:
SUN Fei,MA JunHua,WANG JingNan,GU MingJun,. Effects of α-thioctic acid on the promotion of bone formation in elderly men with type 2 diabetes mellitus[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2017; 17(6): 415-418.
1. Heinemann D F.Osteoporosis.An overview of the National Osteoporosis Foundation clinical practice guide[J].Geriatrics,2000,55(5):31-36.
2. Adler R A.Osteoporosis in men: insights for the clinician[J].Ther Adv Musculoskel Dis,2011,3(4):191-200.
3. Bass E,French D D,Bradham D D,et al.Risk-adjusted mortality rates of elderly veterans with hip fractures[J].Ann Epidemiol,2007,17(7):514-519.
4. Jiang H X,Majumdar S R,Dick D A,et al.Development and initial validation of a risk score for predicting in-hospital and 1-year mortality in patients with hip fractures[J].J Bone Miner Res,2005,20(3):494-500.
5. XIA JinWei,ZHONG Yuan,HUANG GaoZhong,et al.The relationship between insulin resistance and osteoporosis in elderly male type 2 diabetes mellitus and diabetic nephropathy[J].Ann Endocrinol(Paris),2012,73(6):546-551.
6. Koh W P,WANG RenWei,Ang L W,et al. Diabetes and risk of hip fracture in the Singapore Chinese health study[J].Diabetes Care,2010,33(8):1766-1770.
7. CHEN HaiLing,DENG LiLi,LI JuFen.Prevalence of osteoporosis and its associated factors among older men with type 2 diabetes[J].Int J endocrinol,2013,2013:ID285729.
8. GUO Jing,LU Fei,JIN RunLin,et al. Application and analysis of clinical off-label use of thioctic acid injection[J].Pharm Care Res,2016,16(6):464-467.In Chinese with English abstract.
9. FU Chao,XU Dong,WANG ChangYuan,et al. Alpha-lipoic acid promotes osteoblastic formation in H2O2-treated MC3T3-E1 cells and prevents bone loss in ovariectomized rats[J].J Cell Physiol,2015,230(9):2184-2201.
10. Shanbhogue V V,Mitchell D M,Rosen C J,et al.Type 2 diabetes and the skeleton: new insights into sweet bones[J].Lancet Diabetes Endocrinol,2016,4(2):159-173.
11. Carnevale V,Romagnoli E,D’Erasmo E.Skeletal involvement in patients with diabetes mellitus[J].Diabetes Metab Res Rev,2004,20(3):196-204.
12. Melton L J Ⅲ,Riggs B L,Leibson C L,et al.A bone structural basis for fracture risk in diabetes[J].J Clin Endocrinol Metab,2008,93(12):4804-4809.
13. Yu E W,Putman M S,Derrico N,et al. Defects in cortical microarchitecture among African-American women with type 2 diabetes[J].Osteoporos Int,2015,26(2):673-679.
14. ZHOU XueYing,XIA WeiBo.Biochemical markers of bone turnover[J].Basic Clin Med,2007,27(10):1093-1100.In Chinese with English abstract.
15. Polat B,Halici Z,Cadirci E,et al. The effect of alpha-lipoic acid in ovariectomy and inflammation-mediated osteoporosis on the skeletal status of rat bone[J].Eur J Pharmacol,2013,718(1-3):469-474.
16. YANG Lei,MENG HongZheng,YANG MaoWei.Autophagy protects osteoblasts from advanced glycation end products-induced apoptosis through intracellular reactive oxygen species[J].J Mol Endocrinol,2016,56(4):291-300.
17. Park S,Karunakaran U,Jeoung N H,et al.Physiological effect and therapeutic application of alpha lipoic acid[J].Curr Med Chem,2014,21(32):3636-3645.
18. Rochette L,Ghibu S,Muresan A,et al. Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes[J].Can J Physiol Pharmacol,2015,93(12):1021-1027.
《药学服务与研究》杂志社 All Rights Reserved 网站备案号:鲁B2-20061008
·地址:上海市杨浦区长海路168号18号楼东三楼 邮政编码:200433
·联系电话(传真):86-21-65519829, 021-31162330