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Pharmaceutical Care and Research: 2017; 17(6):432-436
DOI: 10.5428/pcar20170611
Preparation and pharmacodynamics study of compound ropivacaine cream
1. DU WenXia1(1.Department of Respiration,Fifth People’s Hospital of Qinghai Province,Xining 810007,China
2. QIAN Jin2(2.Department of Pharmacy,Changhai Hospital,Second Military Medical University, Shanghai 200433,China
3. YUE MingYue2(2.Department of Pharmacy,Changhai Hospital,Second Military Medical University, Shanghai 200433,China )
4. WANG Ting2(2.Department of Pharmacy,Changhai Hospital,Second Military Medical University, Shanghai 200433,China )
5. LIU JiYong2(2.Department of Pharmacy,Changhai Hospital,Second Military Medical University, Shanghai 200433,China
ABSTRACT  Objective: To prepare the compound ropivacaine cream and perform research on the contents,in vitro permeability and in vivo pharmacodynamics.Methods: Compound ropivacaine cream was prepared by using ropivacaine and lidocaine as the main ingredients,and stearyl alcohol,polyethylene glycol-7-stearate and light white mineral oil as the cream base.The contents of lidocaine and ropivacaine in the cream were detected by HPLC method.In vitro permeability experiment of the cream was performed by using Franz diffusion cells,and hot plate and writhing tests were applied to study the in vivo pharmacodynamics of the cream.Results: The content of the prepared compound ropivacaine cream was uniform with good in vitro transdermal permeability,which obviously increased the pain threshold by hot plate and writhing and displayed good dose effect.Conclusion: The compound ropivacaine cream could be applied in local anesthesia clinically.
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DU WenXia1,QIAN Jin2,YUE MingYue2,WANG Ting2,LIU JiYong2,. Preparation and pharmacodynamics study of compound ropivacaine cream[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2017; 17(6): 432-436.
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