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Pharmaceutical Care and Research: 2017; 17(6):445-448
DOI: 10.5428/pcar20170614
Prolonged and low-dose adefovir dipivoxil therapy related kidney injury in patients with chronic hepatitis B
1. LIU YaYun(Department of Infectious Disease,Changhai Hospital,Second Military Medical University,Shanghai 200433,China
2. LIANG XueSong(Department of Infectious Disease,Changhai Hospital,Second Military Medical University,Shanghai 200433,China
ABSTRACT  Objective: To attract the attention of the people to adefovir dipivoxil (ADV) therapy related kidney injury in patients with chronic hepatitis B (CHB).Methods: By reporting therapy related injury induced by prolonged ADV antiviral treatment in the 2 cases of CHB and reviewing related literature,clinical features,risk factors,clinical treatment and prognosis of kidney injury induced by prolonged use of low-dose ADV were described.Results: Initial clinical manifestations of the ADV-related kidney injury were various,and early detection and in-time withdrawal of the drug would enable patients to recover.However,delayed diagnosis would result in irreversible kidney injury.Conclusion: Clinicians should pay full attention to the ADV-related kidney injury.Regardless of ADV dosage,close clinical follow-ups should be implemented in the patients with prolonged application of ADV.
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LIU YaYun,LIANG XueSong,. Prolonged and low-dose adefovir dipivoxil therapy related kidney injury in patients with chronic hepatitis B[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2017; 17(6): 445-448.
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