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Abstract
Pharmaceutical Care and Research: 2017; 17(6):457-460
DOI: 10.5428/pcar20170617
Clinical analysis of 84 cases of adverse drug reactions induced by antiepileptic drugs
1. DING YiDuo(Department of Pharmacy,First Hospital Affiliated to Soochow University,Jiangsu Suzhou 215006,China 150440089@qq.com)
2. QIAN YuLan(Department of Pharmacy,First Hospital Affiliated to Soochow University,Jiangsu Suzhou 215006,China )
3. GAO Jie(Department of Pharmacy,First Hospital Affiliated to Soochow University,Jiangsu Suzhou 215006,China )
4. YU Di(Department of Pharmacy,First Hospital Affiliated to Soochow University,Jiangsu Suzhou 215006,China )
5. XIE Cheng(Department of Pharmacy,First Hospital Affiliated to Soochow University,Jiangsu Suzhou 215006,China xiecheng_1999@163.com)
ABSTRACT  Objective: To investigate the occurrence and characteristics of adverse drug reactions (ADRs) induced by antiepileptic drugs (AEDs),so as to provide reference for rational use of drugs clinically.Methods: The ADRs induced by AEDs from May 2004 to December 2016 in the First Hospital Affiliated to Soochow University were enrolled for the study.Drug variety,clinical manifestations,severity and outcomes of the ADRs were analyzed respectively.Results: There were 84 cases (involved 89 AEDs and 91 systems-organs) of ADRs induced by AEDs,mainly involving carbamazepine 43/91 (47.3%),oxcarbazepine 15/91 (16.5%) and sodium valproate 9/91 (9.9%).Main impairment was associated with skin and appendices 64/91 (70.3%),of which the cases of drug-induced hypersensitivity syndrome (DIHS),Stevense-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) accounted for 12/91 (13.2%),14/91 (15.4%) and 6/91 (6.6%),respectively.Of the 29 cases treated with carbamazepin or oxcarbazepine and seized with DIHS,SJS or TEN,6 cases received HLA-B * 1502 allelic genetic test,and detection results were all positive.Serum drug concentrations in the 2 cases of ADRs induced by phenytoin sodium were 29.7μg/ml and 36.6μg/ml,respectively.Conclusion: In the course of treatment with AEDs,special attention should be paid to those with idiosyncratic reactions.At the same time,genetic test and therapeutic drug monitoring should be performed and medication education be implemented to ensure safe and effective application of AEDs.
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Please cite this article as:
DING YiDuo,QIAN YuLan,GAO Jie,YU Di,XIE Cheng,. Clinical analysis of 84 cases of adverse drug reactions induced by antiepileptic drugs[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2017; 17(6): 457-460.
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