Your Navigation:PCAR > Abstract
Search pcar
检索项:
检索词:
Abstract
Pharmaceutical Care and Research: 2019; 19(1):29-31
DOI: 10.5428/pcar20190108
Study on efficacy and safety of ectopic pregnancy Ⅱ prescription on ectopic pregnancy
1. ZHENG Chunmei(Department of Pharmacy,Maternity and Child Healthcare Hospital of Shenzhen Nanshan District,Guangdong Shenzhen 518000,China 76037761@qq.com)
2. LIU Xiaofeng(Department of Pharmacy,Maternity and Child Healthcare Hospital of Shenzhen Nanshan District,Guangdong Shenzhen 518000,China )
ABSTRACT  Objective: To study the efficacy and safety of ectopic pregnancy Ⅱ prescription as a monotherapy in the treatment of ectopic pregnancy.Methods: 160 patients with ectopic pregnancy from December 2015 to December 2017 in the Maternity and Child Healthcare Hospital of Shenzhen Nanshan District were included and randomly divided into two groups.The patients in the control group were treated with methotrexate at a dosage of 50 mg/m2 intramuscularly injected for the first time.Seven days later,the patients were reexamined.Different doses of methotrexate were given according to the reexamination results,and then,the patients were reexamined every other day.Patients in the treatment group were treated with ectopic pregnancy Ⅱ prescription,1 dose per day,for a succession of more than 7 days.The blood level and recovery time to normal value of β-human chorionic gonadotropin(β-HCG),lump size,lump disappearance time,hospitalization days,treatment effective rate and rate of adverse drug reactions(ADRs) were compared between the two groups.Results: Therapeutic efficacy of the treatment group was significantly higher than that of the control group,and the difference was statistically significant(95.0% vs 83.8%,P<0.05).The rate of ADRs in the treatment group was significantly lower than that in the control group,also with statistical significance (6.3% vs 20.0%,P<0.05).Seven days after treatment,the blood level of β-HCG [(5.13±1.82) ng/ml vs (7.62±2.30) ng/ml],lump size[(1.05±0.37) cm vs (1.87±0.62) cm],recovery time to normal value of β-HCG [(12.27±2.59) d vs (15.31±3.22) d],lump disappearance time[(14.87±2.31) d vs (20.53±3.47) d],hospitalization days [(13.59±3.11) d vs (19.62±2.57) d] in the treatment group were significantly lower or less than those in the control group(P<0.05,P<0.01).Conclusion: The treatment of ectopic pregnancy with ectopic pregnancy Ⅱ prescription could improve effective rate,accelerate lump disappearance,and lower the rate of ADRs.However,it might prolong the vaginal bleeding of certain patients,so attention should be paid to the rational use of ectopic pregnancy Ⅱ prescription.
Welcome to PCAR! You are the number 270 reader of this article!
Please cite this article as:
ZHENG Chunmei,LIU Xiaofeng,. Study on efficacy and safety of ectopic pregnancy Ⅱ prescription on ectopic pregnancy[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2019; 19(1): 29-31.
References:
1. HAO Ming,LIU Liping.Clinical effect of different dose regimens of methotrexate in treatment of unruptured ectopic pregnancy[J].Clin Misdiagn Misther,2011,24(10):38-40.In Chinese with English abstract.
2. DAI Huibo,LIU Yuhua.Clinical efficacy and adverse reactions of methotrexate combined with mifepristone in treatment of ectopic pregnancy[J].Maternal Child Health Care China,2016,31(17):3570-3572.In Chinese with English abstract.
3. ZHANG Chunxia,ZHANG Xinlian,WANG XuePing.Clinical study of ectopic pregnancy treatment with combined therapy of methotrexate and ectopic pregnancy Ⅱ prescription[J].J Pract Tradit Chin Med,2017,33(5):539-540.In Chinese.
4. WU Xiongjun.Curative effect of methotrexate combined with mifepristone,laparotomy,and laparoscopic surgery for treatment of ectopic pregnancy[J].Maternal Child Health Care China,2013,28(5):814-816.In Chinese with English abstract.
5. CHEN Hailin,WAN Hui,ZHANG Chunlian.Clinical analysis of different schemes in methotrexate conservative treatment of ectopic pregnancy[J].Pract J Clin Med,2013,10(1):119-120.In Chinese with English abstract.
6. GU Jinyun,XU Wen,LI Yi.Analysis of the efficacy and adverse reactions of methotrexate in unruptured ectopic pregnancy patients[J].China Med Herald,2013,10(34):65-67.In Chinese with English abstract.
《药学服务与研究》杂志社 All Rights Reserved 网站备案号:鲁B2-20061008
·地址:上海市杨浦区长海路168号18号楼东三楼 邮政编码:200433
·联系电话(传真):86-21-65519829, 021-31162330
·电子邮件:PharmCR@vip.163.com
·技术支持:中国康网
管理员入口