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Abstract
Pharmaceutical Care and Research: 2019; 19(1):10-15
DOI: 10.5428/pcar20190104
Revision of the rating standards for the evaluation of damage caused by adverse drug reactions and the application in 1494 case reports
1. CHENG Jingjing1(1.Deptartment of Pharmacy,Changhai Hospital,Navy Military Medical University,Shanghai 200433,China jinganswer_890721@126.com)
2. 3(3.Deptartment of Pharmacy,He’nan Provincial Corps Hospital of Chinese People’s Armed Police,Zhengzhou 450000,China jinganswer_890721@126.com)
3. WANG Ya1(1.Deptartment of Pharmacy,Changhai Hospital,Navy Military Medical University,Shanghai 200433,China )
4. ZHANG Ling2(2.Market Supervision and Administration Bureau of Yangpu District of Shanghai,Shanghai 200090,China )
5. WANG Zhuo1(1.Deptartment of Pharmacy,Changhai Hospital,Navy Military Medical University,Shanghai 200433,China wangzhuo088@163.com)
ABSTRACT  Objective: To further elaborate the published rating standards for the evaluation of damage caused by adverse drug reactions (ADRs) and develop the new and more practical rating standards,and then,the 2 standards were applied in ADRs reports.The scores of every case were evaluated and effects after elaboration were compared.Methods: Twenty medical and health experts were consulted by Delphi method by way of questionnaire,and 2 rounds of questionnaire survey were performed.Then,statistical analysis was made on the retrieved data.Data scores for each index in the new evaluation standards were derived from ADR-induced damage,on which the new rating standards were revised.Cases of ADRs were analyzed and evaluated respectively by the new and old rating standards.Results:The new rating standards developed through study contained 17 items or indexes ranging from light to severe,with a defined component scores of 9 to 100.In the 1494 case reports,ordinary ADRs reports accounted for 85.81%,new ordinary ADRs reports accounted for 12.58%,severe ADRs reports accounted for 1.07% and new and severe ADRs reports accounted for 0.54%.Differences could be seen in the order of data value of SIADRs derived from the 2 rating standards.Conclusion:The newly developed rating standards for the evaluation of damage caused by ADRs were more elaborate,accurate and definitely more practical,as compared with those published previously,and the application of which was of great significance for the prediction of drug safety in clinical medication.
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Please cite this article as:
CHENG Jingjing1,3,WANG Ya1,ZHANG Ling2,WANG Zhuo1,. Revision of the rating standards for the evaluation of damage caused by adverse drug reactions and the application in 1494 case reports[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2019; 19(1): 10-15.
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