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Abstract
Pharmaceutical Care and Research: 2019; 19(1):52-58
DOI: 10.5428/pcar20190113
Efficacy of retention enema with Chinese materia medica in the treatment of ulcerative colitis:a meta analysis
1. NI Xiaoxia(Department of Pharmacy,No.909 Hospital of Joint Logistics Support Force/Southeast Hospital Affilated to Xiamen Univesty,Fujian Zhangzhou 363000,China lanxueweini@163.com)
2. WANG Qingfen(Department of Pharmacy,No.909 Hospital of Joint Logistics Support Force/Southeast Hospital Affilated to Xiamen Univesty,Fujian Zhangzhou 363000,China )
3. LIU Xiaoling(Department of Pharmacy,No.909 Hospital of Joint Logistics Support Force/Southeast Hospital Affilated to Xiamen Univesty,Fujian Zhangzhou 363000,China )
4. YE Caifa(Department of Pharmacy,No.909 Hospital of Joint Logistics Support Force/Southeast Hospital Affilated to Xiamen Univesty,Fujian Zhangzhou 363000,China )
5. CHEN Jinshan(Department of Pharmacy,No.909 Hospital of Joint Logistics Support Force/Southeast Hospital Affilated to Xiamen Univesty,Fujian Zhangzhou 363000,China cjs1223@sohu.com)
ABSTRACT  Objective: To systematically evaluate the efficacy and safety of retention enema with Chinese materia medica in the treatment of ulcerative colitis(UC).Methods: The databases,such as Cochrane Library,PubMed,the Chinese Journal Full-text Database in China National Knowledge Infrastructure(CNKI),the Chinese Biomedical Literature Database(CBM),Wanfang data and the China Science and Technology Journal Database(VIP) were searched from the inception to July,2017 to collect randomized controlled trials (RCT) in the treatment of UC by retention enema with Chinese materia medica,according to Cochrane Collaboration system review.After data collection and quality evaluation,meta analysis was performed using RevMan 5.3 software.Results: A total of 36 RCTs were included.Results of meta analysis showed that total efficacy of the treatment group was higher than that of the control group[RR=1.20,95%CI(1.15,1.25),P<0.000 01].After treatment,the traditional Chinese medical syndrome scores of the treatment group were lower than those of the control group.The endoscopic scores of the treatment group were lower than those of the control group .The recurrent rate of the treatment group was lower than that of the control group[RR=0.36,95%CI(0.25,0.52),P<0.000 01].The rate of adverse drug reactions(ADRs) of the treatment group was also lower than that of the control group [RR=0.23,95%CI(0.12,0.44),P<0.000 1].Conclusion: Current limited evidence suggests that retention enema with Chinese materia medica in the treatment of UC could improve total efficacy of the treatment,alleviate the related symptoms and reduce the recurrent rate and the rate of ADRs in UC.
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Please cite this article as:
NI Xiaoxia,WANG Qingfen,LIU Xiaoling,YE Caifa,CHEN Jinshan,. Efficacy of retention enema with Chinese materia medica in the treatment of ulcerative colitis:a meta analysis[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2019; 19(1): 52-58.
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