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Abstract
Pharmaceutical Care and Research: 2007; 7(5):335-338
Advance in research on tumstatin active peptides and their derivatives
1. HE Xin(Institute of Radiation Medicine,Chinese Academy of Medical Sciences & Peking Union Medical College,Tianjin 300192,China saluoo@163.com)
2. ZHAO Qi-ren(Institute of Radiation Medicine,Chinese Academy of Medical Sciences & Peking Union Medical College,Tianjin 300192,China )
3. SONG Na-ling(Institute of Radiation Medicine,Chinese Academy of Medical Sciences & Peking Union Medical College,Tianjin 300192,China zhaoqiren98@yahoo.com.cn)
ABSTRACT  After the development of angiostatin and endostatin,tumstatin,which is derived from human vascular basement membrane component-type Ⅳ collagen,came out as a tumor inhibitory factor with great potential.Its bioactivities,such as antitumor angiogenic activity,apoptosis induction of tumor cells and endothelial cells,have made it to be a hot research spot.In this article,the advance in research on tumstatin active peptides and their derivatives are introduced and the bioactivities of Tum-5,T7 and 19 peptides and the derivants of these active peptides linking with NGR sequence or human IgG3 hinge region are summarized in detail.Tumstatin active peptides and their derivants have been being promising candidates for the treatment of cancer,showing their features of high selectivity and activity as well as low toxicity.
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Please cite this article as:
HE Xin,ZHAO Qi-ren,SONG Na-ling,. Advance in research on tumstatin active peptides and their derivatives[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2007; 7(5): 335-338.
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