Your Navigation:PCAR > Abstract
Search pcar
Pharmaceutical Care and Research: 2007; 7(5):335-338
Advance in research on tumstatin active peptides and their derivatives
1. HE Xin(Institute of Radiation Medicine,Chinese Academy of Medical Sciences & Peking Union Medical College,Tianjin 300192,China
2. ZHAO Qi-ren(Institute of Radiation Medicine,Chinese Academy of Medical Sciences & Peking Union Medical College,Tianjin 300192,China )
3. SONG Na-ling(Institute of Radiation Medicine,Chinese Academy of Medical Sciences & Peking Union Medical College,Tianjin 300192,China
ABSTRACT  After the development of angiostatin and endostatin,tumstatin,which is derived from human vascular basement membrane component-type Ⅳ collagen,came out as a tumor inhibitory factor with great potential.Its bioactivities,such as antitumor angiogenic activity,apoptosis induction of tumor cells and endothelial cells,have made it to be a hot research spot.In this article,the advance in research on tumstatin active peptides and their derivatives are introduced and the bioactivities of Tum-5,T7 and 19 peptides and the derivants of these active peptides linking with NGR sequence or human IgG3 hinge region are summarized in detail.Tumstatin active peptides and their derivants have been being promising candidates for the treatment of cancer,showing their features of high selectivity and activity as well as low toxicity.
Welcome to PCAR! You are the number 1929 reader of this article!
Please cite this article as:
HE Xin,ZHAO Qi-ren,SONG Na-ling,. Advance in research on tumstatin active peptides and their derivatives[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2007; 7(5): 335-338.
1. Folkman J. Tumor angiogenesis:therapeutic implications[J]. N Engl J Med, 1971,285(21):1182-1186
2. Hlatky L,Hahnfeldt P,Folkman J. Clinical application of antiangiogenic therapy:microvessel density,what it does and doesn't tell us[J]. J Natl Cancer Inst, 2002,94(12):883-893
3. Maeshima Y,Colorado P C,Torre A,et al. Distinct antitumor properties of a type Ⅳ collagen domain derived from basement membrane[J]. J Biol Chem, 2000,275(28):21340-21348
4. O'Reilly M S,Boehm T,Shing Y,et al. Endostatin:an endogenous inhibitor of angiogenesis and tumor growth[J]. Cell, 1997,88(2):277-285
5. Colorado P C,Torre A,Kamphaus G,et al. Anti-angiogenic cues from vascular basement membrane collagen[J]. Cancer Res, 2000,60(9):2520-2526
6. Kamphaus G D,Colorado P C,Panka D J,et al. Canstatin,a novel matrix-derived inhibitor of angiogenesis and tumor growth[J]. J Biol Chem, 2000,275(2):1209-1215
7. Kashtan C E. Alport syndrome and thin glomerular basement membrane disease[J]. J Am Soc Nephrol, 1998,9(9):1736-1750
8. Teodoro J G,Parker A E,Zhu X,et al. p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase[J]. Science, 2006,313(5789):968-971
9. Maeshima Y,Colorado P C,Kalluri R. Two RGD-independent αvβ3 integrin binding sites on tumstatin regulate distinct anti-tumor properties[J]. J Biol Chem, 2000,275(31):23745-23750
10. Petitclerc E,Boutaud A,Prestayko A,et al. New functions for non-collagenous domains of human collagen type Ⅳ.Novel integrin ligands inhibiting angiogenesis and tumor growth in vivo[J]. J Biol Chem, 2000,275(11):8051-8061
11. Maeshima Y,Manfredi M,Reimer C,et al. Identification of the anti-angiogenic site within vascular basement membrane-derived tumstatin[J]. J Biol Chem, 2001,276(18):15240-15248
12. Maeshima Y,Yerramalla U L,Dhanabal M,et al. Extracellular matrix-derived peptide binds to αvβ3 integrin and inhibits angiogenesis[J]. J Biol Chem, 2001,276(34):31959-31968
13. Frojdman K,Pelliniemi L J,Virtanen I. Differential distribution of type Ⅳ collagen chains in the developing rat testis and ovary[J]. Differentiation, 1998,63(3):125-130
14. FU Xue, WANG Shu-Jing, LIN Xue-Song, et al. Study on expression and biological activity of anti-angiogenic peptide of tumstatin[J]. Journal of Medical Molecular Biology, 2005,2(3):157-161
15. WANG Shu-Jing, LIU Yan, LIN Xue-Song, et al. Cloning and biological activity of anti-tumor peptide of tumstatin[J]. Chinese Journal of Biochemistry and Molecular Biology, 2005,21(3):322-328
16. Floquet N,Pasco S,Ramont L,et al. The antitumor properties of the α3 (Ⅳ)-(185-203) peptide from the NC1 domain of type Ⅳ collagen (tumstatin) are conformation-dependent[J]. J Biol Chem, 2004,279(3):2091-2100
17. Pasco S,Han J,Gillery P,et al. A specific sequence of the noncollagenous domain of the α3 (Ⅳ) chain of type Ⅳ collagen inhibits expression and activation of matrix metalloproteinases by tumor cells[J]. Cancer Res, 2000,60(2):467-473
18. Pasqualini R,Koivunen E,Kain R,et al. Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis[J]. Cancer Res, 2000,60(3):722-727
19. PENG Shu-Ping, FANG Wei-Yi, JIANG Ri-Cheng, et al. Prokaryotic expression of vascular basement membrane-derived multifunctional peptide and its anti-tumor activity assay[J]. Chinese Pharmacological Bulletin, 2003,19(6):678-682
20. ZHOU Hong, DAI Wen-Jian, PENG Shu-Ping, et al. Expression of vascular basement membrane-derived multifunctional peptide gene in Pichia pastoris and activity identification[J]. American Journal of Chinese Clinical Medicine, 2005,7(1):37-42
21. Miyoshi T,Hirohata S,Ogawa H,et al. Tumor-specific expression of the RGD-α3(Ⅳ)NC1 domain suppresses endothelial tube formation and tumor growth in mice[J]. FASEB J, 2006,20(11):1904-1906
22. Maeshima Y,Sudhakar A,Lively J C,et al. Tumstatin, an endothelial cell-specific inhibitor of protein synthesis[J]. Science, 2002,295(5552):140-143
《药学服务与研究》杂志社 All Rights Reserved 网站备案号:鲁B2-20061008
·地址:上海市杨浦区长海路168号18号楼东三楼 邮政编码:200433
·联系电话(传真):86-21-65519829, 021-31162330