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Abstract
Pharmaceutical Care and Research: 2007; 7(5):339-342
Preparation and release characteristics in vitro of gastric floating sustained-release tablets of sodium ferulate
1. DENG Jia-xin(Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China dengjiaxin007@163.com)
2. HU Jin-hong(Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China hujh@smmu.edu.cn)
3. LI Feng-qian(Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China )
ABSTRACT  Objective: To prepare gastric floating sustained-release tablets of sodium ferulate and evaluate its release characteristics in vitro. Methods: The sustained-release tablets were prepared by direct powder compression technique with hydroxypropyl methyl cellulose(HPMC) as hydrophilic gel-matrix and sodium bicarbonate as the foaming agent. The floating capability and release profile in vitro were used as indicators to evaluate and optimize the formulation. The effects of different preparation methods and HPMC type on release characteristics in vitro were also observed. Results: The optimal formulation could maintain floating on gastric fluid for over 8 hours. In vitro release (8 h) achieved 62% which significantly higher than the common tablets' 49%. Conclusion: The tablets exhibit quick floating and ideal sustained-release characteristics in vitro.
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Please cite this article as:
DENG Jia-xin,HU Jin-hong,LI Feng-qian,. Preparation and release characteristics in vitro of gastric floating sustained-release tablets of sodium ferulate[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2007; 7(5): 339-342.
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