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Abstract
Pharmaceutical Care and Research: 2007; 7(5):347-349
Studies on the chemical constituents of flavones of Veratrum nigrum L.
1. WANG Bin1(1.Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China wangbin_2k@sina.com)
2. LI Hui-liang1(1.Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China )
3. TANG Jian2(2.Department of Pharmaceutical Chemistry, School of Pharmacy, Shanghai Jiaotong University, Shanghai 200030, China )
4. ZHANG Wei-dong1(1.Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China wdzhangy@hotmail.com)
5. 2(2.Department of Pharmaceutical Chemistry, School of Pharmacy, Shanghai Jiaotong University, Shanghai 200030, China )
ABSTRACT  Objective: To investigate the chemical constituents of flavones of Veratrum nigrum L.. Methods: The compounds were isolated by repeated column chromatography over Sephadex LH-20, RP C18 and silica gel. The compounds obtained were identified according to their physicochemical properties and spectral data (UV, ESI-MS, 1H-NMR and13C-NMR). Results: Nine compounds were isolated and identified as 3-methoxylisorhamnetin (1), isorhamnetin (2), 3-methoxylquercetin (3), quercetin (4), isoquercitrin (5), 3,5,7-trihydroxy-3′,5′ -dimethoxylflavone (6), 5,7,4′-trihydroxy-3′-methoxylflavone (7), 5,7,3′,4′-tetrahydroxyflavone (8), 5,7,3′,5′-tetrahydroxyflavone (9), respectively. Conclusion: All of the compounds 1-9 are separated from Veratrum nigrum L. for the first time.
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Please cite this article as:
WANG Bin1,LI Hui-liang1,TANG Jian2,ZHANG Wei-dong1,2,. Studies on the chemical constituents of flavones of Veratrum nigrum L.[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2007; 7(5): 347-349.
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