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Abstract
Pharmaceutical Care and Research: 2007; 7(5):364-366
Pharmacokinetics and relative bioavailability of azithromycin tablets in healthy volunteers
1. TANG Shi-xin(Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433,China ahtsx@163.com)
2. LI Zhen(Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433,China lizhen-01@163.com)
3. JI Yi-ping(Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433,China )
4. YANG Wu-yun(Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433,China )
5. HU Jin-hong(Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433,China )
ABSTRACT  Objective: To investigate the concentration-time profile and the relative bioavailability of test azithromycin tablets. Methods: A single oral dose of 500 mg azithromycin was given in a randomized, cross-over study in 20 healthy volunteers. Serum concentrations of azithromycin were determined by microbiological assay. Results: Concentration-time profile of the test tablet was well fitted to that of the reference tablets.The main pharmacokinetic parameters of the test and reference tablet were as follows: cmax (468.54±136.53) and (473.37±131.51) ng/mL,tmax (1.98±0.72) and (2.00±0.74) h,t1/2 (39.35±8.08) and (41.23±7.94) h,AUC0~!44 (4 525.84±1 002.73) and (4 723.06±1 018.60) ng·h·mL-1. Conclusion: The results of statistical analysis showed that two formulations were bioequivalent. The relative bioavailability of test tablet is (96.27±10.22)%.
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Please cite this article as:
TANG Shi-xin,LI Zhen,JI Yi-ping,YANG Wu-yun,HU Jin-hong,. Pharmacokinetics and relative bioavailability of azithromycin tablets in healthy volunteers[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2007; 7(5): 364-366.
References:
1. ZHANG Jing, GUO Bei-Ning, ZHANG Ying-Yuan. Clinical pharmacokinetis study on azithromycin[J]. The Chinese Journal of Clinical Pharmacology, 1996,12(2):89-92
2. QIAO Hai-Ling, ZHANG Li-Rong, ZHANG Qi-Tang, et al. Study on pharmacokinetics and relative bioavailability of azithromycin in healthy volunteers[J]. Chinese Journal of Hospital Pharmacy, 1998,18(7):293-295
3. CHU Xiao-Man, ZHOU Yan, CAO Xiao-Mei, et al. Pharmacokinetics and relative bioavailability of domestic azithromycin dispersible tablets in healthy volunteers[J]. Chinese Journal of Hospital Pharmacy, 2000,20(10):592-594
4. SHI Jing, Song-Hong-Jie, LI Zhen, et al. Pharmacokinetics and relative bioavailability of azithromycin tablets[J]. Chinese Journal of Pharmaceuticals, 2001,32(5):215-216
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