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Pharmaceutical Care and Research: 2017; 17(6):401-404
DOI: 10.5428/pcar20170601
Advances in the mechanisms of butylphthalide and its derivatives for treatment of stroke
1. XUE ChaoJun(Department of Pharmacy,People’s Hospital of Hebei Province,Shijiazhuang 050000,China
2. JIN HuiXin(Department of Pharmacy,People’s Hospital of Hebei Province,Shijiazhuang 050000,China )
3. ZHANG XuDong(Department of Pharmacy,People’s Hospital of Hebei Province,Shijiazhuang 050000,China
ABSTRACT  Butylphthalide,the first class new cardiovascular drug with independent intellectual property rights in China,is used for the treatment of ischemic stroke.In spite of its sound therapeutic effects,it is of poor water solubility,thus making its derivatives a hot research spot.The paper gives a comprehensive review on the mechanisms of butylphthalide and its derivatives in the treatment of stroke from the perspectives of anti-platelet aggregation and formation of anti-thrombosis,mitochondrial protection,neuronal cell protection,anti-oxidative stress and the promotion of nerve regeneration.
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XUE ChaoJun,JIN HuiXin,ZHANG XuDong,. Advances in the mechanisms of butylphthalide and its derivatives for treatment of stroke[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2017; 17(6): 401-404.
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