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Pharmaceutical Care and Research: 2017; 17(6):405-410
DOI: 10.5428/pcar20170602
Advances in signal pathways involved in the treatment of gastric ulcer by natural products
1. ZHANG Jun1(1.Department of Pharmacology,College of Pharmacy,Zhejiang University of Industry,Hangzhou 310014,China
2. FU ZaiLin2( 2.Department of Pharmacy,No.117 Hospital of PLA,Hangzhou 310004,China )
3. SONG BiWei1(1.Department of Pharmacology,College of Pharmacy,Zhejiang University of Industry,Hangzhou 310014,China
ABSTRACT  Gastric ulcer is a common disease of digestive system caused by many factors.Although the clinical cure rate of gastric ulcer is high clinically,the relapse rate is also high.Natural products have become an increasing concern because of their remarkable curative effect,low relapse rate and less side effects in the treatment of gastric ulcer.This article reviews the current advances in the signal pathways involved in the treatment of gastric ulcer by natural products.
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ZHANG Jun1,FU ZaiLin2,SONG BiWei1,. Advances in signal pathways involved in the treatment of gastric ulcer by natural products[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2017; 17(6): 405-410.
1. LIU LiJuan,HAI LiNa,ZHANG JinLing,et al.Literature review of TCM medication rules in treating gastric ulcer[J].World Chin Med,2016,11(3):546-549.In Chinese with English abstract.
2. Hung Y P,Ko W C,Chou P H,et al.Proton pump inhibitor exposure aggravates Clostridium difficile-assoiated colitis: evidence from a mouse model[J].J Infect Dis,2015,212(4):654-663.
3. Dhanasekaran D N,Reddy E P.JNK signaling in apoptosis[J].Oncogene,2008,27(48):6245-6251.
4. LUO XiuJu,LIU Bin,DAI Zhong,et al.Expression of apoptosis-associated microRNAs in ethanol-induced acute gastric mucosal injury via JNK pathway[J].Alcohol,2013,47(6):481-493.
5. LIU Jing,LI ZhaoShen,WAN XinJian,et al.Expression and function of apoptosis-related genes Bcl-2/Bax and Fas/Fas L in the course of stress ulcer[J].Natl Med J China,2003,83(6):504-509.In Chinese with English abstract.
6. Yadav S K,Adhikary B,Bandyopadhyay S K,et al.Inhibition of TNF-α,and NF-κB and JNK pathways accounts for the prophylactic action of the natural phenolic,allylpyrocatechol against indomethacin gastropathy[J].Biochim Biophys Acta,2013,1830(6):3776-3786.
7. HU HouCai,XIE JianGuang,QIU LiHuang,et al.Research advances in pharmacologic effect for gastrointestinal protection of plants in Artemisia L.and their mechanism[J].Drugs Clin,2012,27(3):304-308.In Chinese with English abstract.
8. Jeong D,Yi Y S,Sung G H,et al.Anti-inflammatory activities and mechanisms of Artemisia asiatica ethanol extract[J].J Ethnopharmacol,2014,152(3):487-496.
9. DasGupta R,Kaykas A,Moon R T,et al.Functional genomic analysis of the Wnt-wingless signaling pathway[J].Science,2005,308(5723):826-833.
10. Whyte J L,Smith A A,Helms J A.Wnt signaling and injury repair[J].Cold Spring Harb Perspect Biol,2012,4(8):a008078.
11. MEI WuXuan,ZENG ChangChun.Effect of boswellia carterii birdw extractive on quality of ulcer healing in rats with gastric ulcer induced by acetic acid[J].Chin J Integr Tradit West Med Dig,2004,12(1):34-36.In Chinese with English abstract.
12. MEI WuXuan,YU Na.Effect of frankincense extract on β-catenin and Cyclin D1 in gastric ulcer rats[J].Chin Arch Tradit Chin Med,2015,33(9):2163-2165.In Chinese with English abstract.
13. LUO XiuJu,PENG Jun,LI YuanJian.Recent advances in the study on capsaicinoids and capsinoids[J].Eur J Pharmacol,2011,650(1):1-7.
14. HUANG Wei,WANG Hui,Galligan J J,et al.Transient receptor potential vanilloid subtype 1 channel-mediated neuropeptide secretion and depressor effects:role of endoplasmic reticulum associated Ca2+ release receptors in rat dorsal root ganglion neurons[J].J Hypertens,2008,26(10):1966-1975.
15. Satyanarayana M N.Capsaicin and gastric ulcers[J].Crit Rev Food Sci Nutr,2006,46(4):275-328.
16. LI NianSheng,LUO XiuJu,DAI Zhong,et al.Beneficial effects of capsiate on ethanol-induced mucosal injury in rats are related to stimulation of calcitonin gene-related peptide release[J].Planta Med,2012,78(1):24-30.
17. Bartel D P.MicroRNAs: genomics,biogenesis,mechanism,and function[J].Cell,2004,116(2):281-297.
18. REN JianLin,LUO JinYan,LU YaPi,et al.Association of trefoil factor 1 expression with gastric mucosa injuries and gastric cancer[J].J First Mil Med Univ,2005,25(9):1178-1180.In Chinese with English abstract.
19. LIU JingJing,WANG Xu,YANG XiaoNing,et al.miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells[J].Cancer Lett,2014,347(1):98-104.
20. QIN HuiLin,ZHANG YongFeng,WANG XinYi,et al.Effect of ethyl acetate extract from Chaenomeles speciosa (Sweet) Nakai on the expression of miR-423-5p,TFF1 and p53 in acute gastric ulcer mice[J].Pharmacol Clin Chin Mat Med,2016,32(3):80-82.In Chinese with English abstract.
21. Hayden M S,Ghosh S.Regulation of NF-κB by TNF family cytokines[J].Semin Immunol,2014,26(3):253-266.
22. GUAN ShanShan,BAO YongRui,MENG XianSheng,et al.Mechanism underlying promotion of ethanol-induced Ges-1 cell proliferation by saikosaponin through the NF-κB signaling pathway[J].Chin J New Drugs,2013,22(24):2919-2923.In Chinese with English abstract.
23. Verma S,Kumar V L.Attenuation of gastric mucosal damage by artesunate in rat: Modulation of oxidative stress and NF-κB mediated signaling[J].Chem Biol Interact,2016,257:46-53.
24. LI WeiFeng,WANG XiuMei,ZHANG HaiLin,et al.Anti-ulcerogenic effect of cavidine against ethanol-induced acute gastric ulcer in mice and possible underlying mechanism[J].Int Immunopharmacol,2016,38:450-459.
25. HU ZongMiao,LIU JingNan,Zhou YuanLi,et al.Lingzhi Baozhifen(LZBF) attenuates stomach inflammation induced by ethanol in mice[J].Shaanxi J Tradit Chin Med,2016,37(5):632-634.In Chinese with English abstract.
26. CHANG XiaYun,LUO Fen,JIANG WenJiao,et al.Protective activity of salidroside against ethanol-induced gastric ulcer via the MAPK/NF-κB pathway in vivo and in vitro[J].Int Immunopharmacol,2015,28(1):604-615.
27. Aviello G,Canadanovic-Brunet J M,Milic N,et al.Potent antioxidant and genoprotective effects of boeravinone G,a rotenoid isolated from Boerhaavia diffusa[J].PLoS One,2011,6(5):e19628.
28. Kang D H,Han M E,Song M H,et al.The role of hedgehog signaling during gastric regeneration[J].J Gastroenterol,2009,44(5):372-379.
29. Tanaka T,Arai M,Minemura S,et al.Expression level of sonic hedgehog correlated with the speed of gastric mucosa regeneration in artificial gastric ulcers[J].J Gastroenterol Hepatol,2014,29(4):736-741.
30. Ueda K,Ueyama T,Yoshida K,et al.Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions[J].Am J Physiol Gastrointest Liver Physiol,2008,295(3):G460-G469.
31. Luo J C,Lin H Y,Lu C L,et al.Dexamethasone inhibits basic fibroblast growth factor-stimulated gastric epithelial cell proliferation[J].Biochem Pharmacol,2008,76(7):841-849.
32. Duffin R,Shaw C A,Rossi A G.Sildenafil reduces alcohol-induced gastric damage: just say ‘NO’[J].Br J Pharmacol,2008,153(4):623-624.
33. Silva R O,Lucetti L T,Wong D V,et al.Alendronate induces gastric damage by reducing nitric oxide synthase expression and NO/cGMP/KATP signaling pathway[J].Nitric Oxide,2014,40:22-30.
34. Nguyen T,Chai J,Li A,et al.Novel roles of local insulin-like growth factor-1 activation in gastric ulcer healing: promotes actin polymerization,cell proliferation,re-epithelialization,and induces cyclooxygenase-2 in a phosphatidylinositol 3-kinase-dependent manner[J].Am J Pathol,2007,170(4):1219-1228.
35. HUANG Pan,ZHOU ZhengRong,WANG Hao,et al.Effect of the IGF-1/PTEN/Akt/FoxO signaling pathway on the development and healing of water immersion and restraint stress-induced gastric ulcers in rats[J].Int J Mol Med,2012,30(3):650-658.
36. Gilster J,Bacon K,Marlink K,et al.Bismuth subsalicylate increases intracellular Ca2+,MAP-kinase activity,and cell proliferation in normal human gastric mucous epithelial cells[J].Dig Dis Sci,2004,49(3):370-378.
37. WANG HongYan,SUN YunDong,LIU ShiLi,et al.Upregulation of progranulin by Helicobacter pylori in human gastric epithelial cells via p38MAPK and MEK1/2 signaling pathway: role in epithelial cell proliferation and migration[J].FEMS Immunol Med Microbiol,2011,63(1):82-92.
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