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Pharmaceutical Care and Research: 2017; 17(6):453-456
DOI: 10.5428/pcar20170616
Drug-induced acute interstitial nephritis: case report and literature review
1. CHEN Ying1(1.Department of Pharmacy,People’s Hospital of Wuhan University, Wuhan 430060,China
2. HE Juan2(2.Department of Pharmacy,Ruijin Hospital Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China )
3. SONG JinChun1(1.Department of Pharmacy,People’s Hospital of Wuhan University, Wuhan 430060,China )
4. JING Feng3(3.Department of Emergency Intensive Care,Ruijin Hospital Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China
ABSTRACT  Objective: To investigate the clinical characteristics,related risk factors,prevention and treatment strategies of drug-induced acute interstitial nephritis(DAIN).Methods: A case of DAIN caused by antibacterials was reported and related literature was analyzed.Results and Conclusion: Various kinds of antibacterials can cause DAIN with vancomycin being one of the most common drugs.The most typical clinical symptoms of DAIN are fever,rash,increased level of eosinophilia,abnormal routine in urine examination and renal function impairment.Preventive measures against DAIN include reasonable application of antimicrobials and reduction of unnecessary drug combinations.Regular monitoring of the serum drug concentration and renal function should be made when using nephrotoxic drugs.Treatment strategies include early diagnosis and prompt withdrawl of suspected drugs.Application of glucocorticoid is necessary in severe cases.
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CHEN Ying1,HE Juan2,SONG JinChun1,JING Feng3,. Drug-induced acute interstitial nephritis: case report and literature review[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2017; 17(6): 453-456.
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