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Abstract
Pharmaceutical Care and Research: 2017; 17(6):470-472
DOI: 10.5428/pcar20170620
Evaluation of literature on off-label drug use of levocarnitine injection by Jadad scale
1. LU Fei(Department of Pharmacy,Ruijin Hospital Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China lf40677@rhj.com.cn)
2. HU JiaLi(Department of Pharmacy,Ruijin Hospital Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China hujialifudan@163.com)
3. ZHAO AiHua(Department of Pharmacy,Ruijin Hospital Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China )
4. JIN RunLin(Department of Pharmacy,Ruijin Hospital Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China )
ABSTRACT  Objective: To evaluate the literature on off-label drug use of levocarnitine injection by the Jadad scale,so as to assess the medication rationality of levocarnitine injection in Ruijin Hospital Affiliated to School of Medicine,Shanghai Jiaotong University.Methods:All the literature on off-label drug use of levocarnitine injection were included and evaluated by the modified Jadad Scale.Literature with scores of more than 4 were selected as evidence for off-label drug use.Totally 360 prescriptions using levocarnitine injection were randomly selected to analyze the medication rationality of levocarnitine injection in this hospital.Results:Levocarnitine injection was usually used for nutrition myocardium,stablization of cardiac function,improvement of myocardial metabolism and so on in the literature selected by Jadad scale.Prescription reviews revealed that there were 309 cases of supernumerary indication drug use,accounting for 85.83%.Levocarnitine injection was mainly used as adjuvant drugs after cardiac surgery and resection of thoracic tumor,and no adverse drug reactions were reported.Conclusion:It would be a new tool that modified Jadad scale could be used for assessment of medication rationality by screening high quality literature.
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Please cite this article as:
LU Fei,HU JiaLi,ZHAO AiHua,JIN RunLin,. Evaluation of literature on off-label drug use of levocarnitine injection by Jadad scale[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2017; 17(6): 470-472.
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