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Abstract
Pharmaceutical Care and Research: 2018; 18(1):26-28,41
DOI: 10.5428/pcar20180107
Study on the formulation and preparation technology of propranolol hydrochloride cream for treatment of infantile hemangiomas
1. LIU Shan1(1.Department of Pharmacy,Former Guangzhou General Hospital of Guangzhou Military Command,Guangzhou 510010,China scorpions@21cn.com)
2. HUANG XueFeng1(1.Department of Pharmacy,Former Guangzhou General Hospital of Guangzhou Military Command,Guangzhou 510010,China )
3. CHEN LongHao1(1.Department of Pharmacy,Former Guangzhou General Hospital of Guangzhou Military Command,Guangzhou 510010,China )
4. XIE XinMin1(1.Department of Pharmacy,Former Guangzhou General Hospital of Guangzhou Military Command,Guangzhou 510010,China )
5. YUAN Jin1(1.Department of Pharmacy,Former Guangzhou General Hospital of Guangzhou Military Command,Guangzhou 510010,China yuanjin-888@163.com)
6. CHENG Biao2(2.Department of Plastic Surgery, Former Guangzhou General Hospital of Guangzhou Military Command,Guangzhou 510010,China )
ABSTRACT  Objective: To study the formulation and preparation technology of propranolol hydrochloride cream(PHC) for treatment of superficial infantile hemangiomas.Methods: The formulation and preparation technology of PHC were optimized by orthogonal experiment.The optimized formulation contained the proportion of oil phase,water phase and emulsifier,and the optimized technology included emulsifying temperature and speed.Results: The samples prepared by orthogonal experiment were uniform and smooth,and had good color,spreadability and stability.The contents of propranolol hydrochloride were from 99.88% to 102.89% of the labelled content.Conclusion: The PHC formulation was rational with practical preparation technology and stable content of propranolol hydrochloride.
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Please cite this article as:
LIU Shan1,HUANG XueFeng1,CHEN LongHao1,XIE XinMin1,YUAN Jin1,CHENG Biao2,. Study on the formulation and preparation technology of propranolol hydrochloride cream for treatment of infantile hemangiomas[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(1): 26-28,41.
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