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Abstract
Pharmaceutical Care and Research: 2018; 18(1):42-47
DOI: 10.5428/pcar20180111
Meta analysis of Qiliqiangxin capsule combined with trimexazidine in the treatment of chronic heart failure
1. BU LeiLei1(1.Department of Pharmacy,Youfu Hospital of Ezhou City,Hubei Ezhou 436000,China 3089652399@qq.com)
2. GAO XianQiong1(1.Department of Pharmacy,Youfu Hospital of Ezhou City,Hubei Ezhou 436000,China )
3. JIN HaiRong2(2.Department of Cardiology,Youfu Hospital of Ezhou City,Hubei Ezhou 436000,China )
4. CHEN Juan3(3.Department of Cardiology,Ezhou Maternal and Child Health Care Hospital,Hubei Ezhou 436000,China )
5. LIAO Hua4(4.Department of Pharmacy,Huangshi Central Hospital,Edong Medical Group,Hubei Huangshi 435000,China liao71hua@163.com)
ABSTRACT  Objective: To systematically review the efficacy and safety of Qiliqiangxin(QLQX) capsule combined with trimexazidine in the treatment of chronic heart failure (CHF) so as to provide theoretical basis of clinical promotion.Methods: Literature of randomized controlled trials about the treatment of CHF with QLQX capsule combined with trimexazidine on the basis of routine treatment were retrieved from the databases of PubMed,Medline,the databases of China National Knowledge Infrastructure(CNKI),the VIP China Science and Technology Journal Database,Wanfang Data-Digitalization Journals from January 1990 to August 2016.Then meta-analysis was performed with Rev Man 5.2 software.Results: A total of 12 papers involving 1030 patients were included in the study.Meta-analysis showed that as compared with conventional therapy or simple trimexazidine,treatment with QLQX capsule combined with trimexazidine in the CHF patients could significantly improve clinical efficacy [RR=1.25,95%CI(1.18,1.32),P<0.00],increased left ventricular ejection fraction (LVEF) and E peak and A peak ratio (E/A) of mitral flow velocity ,reduced pre N terminal pro brain natriuretic peptide (NT-pro BNP),and meanwhile increased 6-minute walking distance(6MWD).There were no obvious adverse drug reactions.Conclusion: Evidences showed that QLQX capsule combined with trimexazidine could produce significant therapeutic effects on CHF and improve LVEF,NT-pro BNP and 6-minute walking distance,with good safety.For this reason,it is worth further clinical extension.
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Please cite this article as:
BU LeiLei1,GAO XianQiong1,JIN HaiRong2,CHEN Juan3,LIAO Hua4,. Meta analysis of Qiliqiangxin capsule combined with trimexazidine in the treatment of chronic heart failure[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(1): 42-47.
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