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Pharmaceutical Care and Research: 2018; 18(1):63-66
DOI: 10.5428/pcar20180116
Adjustment of drug treatment regimens for critical patients with pneumocystis carinii pneumonia
1. TONG Wei1(1.Department of Pharmacy,Jiangxi Cancer Hospital,Nanchang 330029,China
2. WU Jing2(2.Department of Pharmacy,Hangzhou Obstetrics and Gynecology Hospital,Hangzhou 310008,China )
3. HUANG XingFu3(3.Department of Pharmacy,First People’s Hospital of Qujing,Yunnan Qujing 655000,China )
4. CHEN Hong4(4.Department of Respiration,Ruijin Hospital Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China )
5. FANG Jie5(5.Department of Pharmacy,Ruijin Hospital Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China
ABSTRACT  Objective: To investigate the drug treatment regimens for critical patients with pneumocytis carinii pneumonia (PCP).Methods: Through direct involvement of clinical pharmacists in the whole drug treatment of 2 immonosuppressed patients,the drug treatment regimens for critical patients with PCP were adjusted,and therapeutic drug efficacy was evaluated and adverse drug reactions were closely monitored in the process.Results: The initial anti-infection treatment of immonosuppressed patients with pulmonary infection should cover PCP.When patients were unable to tolerate high doses of sulfamethodxazole-trimethoprim (SMZ-TMP) or initial treatment with SMZ-TMP was invalid,the combination of SMZ-TMP with caspofungin could be recommended to treat critical PCP.Conclusion: Combination of SMZ-TMP with caspofungin for the treatment of severe PCP had the advantages of faster response,better clinical efficacy,and more importantly,lower incidence of adverse drug reactions.
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TONG Wei1,WU Jing2,HUANG XingFu3,CHEN Hong4,FANG Jie5,. Adjustment of drug treatment regimens for critical patients with pneumocystis carinii pneumonia[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(1): 63-66.
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