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Abstract
Pharmaceutical Care and Research: 2018; 18(2):114-116
DOI: 10.5428/pcar20180208
Optimization for the dispensing methods of reducing insoluble particles in rabeprazole sodium intravenous infusion
1. YANG Ting(Department of Pharmacy,Changhai Hospital,Second Military Medical University,Shanghai 200433,China dddmyy@126.com)
2. GAO Shen(Department of Pharmacy,Changhai Hospital,Second Military Medical University,Shanghai 200433,China ggss99@126.com)
ABSTRACT  Objective: To explore the influential factors of insoluble particle number in the rabeprazole sodium intravenous infusion,so as to establish the optimal dispensing method.Methods: Time,light intensity,volume of first infusion and internal pressure of vial were selected as the 4 influential factors.Orthogonal design L8(24) was applied to establish the optimal dispensing method.Results: The four factors had obvious influence on insoluble particle number in the rabeprazole sodium intravenous infusion.The optimal dispensing mode was as follows:the drug powder was initially dissolved in 10 ml 0.9% sodium chloride injection,with a negative pressure of 75 kPa in vial,without light,and the infusion was put to use 1 h after dispensing.The number of insoluble particles in intravenous infusion by optimal mode was about 1/20 of that by traditional mode.Conclusion: Insoluble particle number in the rabeprazole sodium intravenous infusion was significantly reduced by the optimal dispensing mode.
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Please cite this article as:
YANG Ting,GAO Shen,. Optimization for the dispensing methods of reducing insoluble particles in rabeprazole sodium intravenous infusion[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(2): 114-116.
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