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Abstract
Pharmaceutical Care and Research: 2018; 18(2):123-126
DOI: 10.5428/pcar20180211
Efficacy of Ganzaoning granules on the patients with nonalcoholic steatohepatitis
1. ZHANG XiaYan1(1.Department of Pharmacy,Changhai Hospital,Second Military Medical University,Shanghai 200433,China 617880699@qq.com)
2. PENG Hao2(2.Faculty of Traditional Chinese Medicine,Second Military Medical University,Shanghai 200433,China ncxq19811031@163.com)
3. 3(3.Hospital of Traditional Chinese Medicine,Changhai Hospital,Second Military Medical University,Shanghai 200433,China ncxq19811031@163.com)
4. WANG HuaiZhou4(4.Department of Laboratory Diagnosis,Changhai Hospital,Second Military Medical University,Shanghai 200433,China )
5. BIAN YanFang1(1.Department of Pharmacy,Changhai Hospital,Second Military Medical University,Shanghai 200433,China )
6. LU JianYing5(5.Department of Traditional Chinese Medicine,Hefei Branch of Changhai Hospital,Second Military Medical University,Hefei 230000,China )
7. ZHENG GuoYin2(2.Faculty of Traditional Chinese Medicine,Second Military Medical University,Shanghai 200433,China herbzheng@163.com)
8. 3(3.Hospital of Traditional Chinese Medicine,Changhai Hospital,Second Military Medical University,Shanghai 200433,China herbzheng@163.com)
ABSTRACT  Objective: To observe the clinical efficacy of Ganzaoning granules on the patients with nonalcoholic steatohepatitis (NASH).Methods: Totally,395 patients with NASH who sought medical care in Changhai Hospital,Second Military Medical University and Hefei Branch of Changhai Hospital from 2013 to 2016 were enrolled for the study.The patients were given Ganzaoning granules at a dosage of 15 g,twice a day,for a succession of 6 months.Close observations were made on the general conditions,laboratory indicators,single symptom of traditional Chinese medicine(TCM),as well as ultrasonographic detection results for the evaluation of treatment efficacy.Results: There were no significant differences in body mass index (BMI) before and after treatment (P>0.05),while there was statistical significance in abdominal circumference (P<0.05).The main single symptoms of TCM were obviously improved,with an overall effective rate of 83.29%.The levels of TC,TG,and LDL-C were all reduced after the treatment,while there were no significant changes in the level of HDL-C,when comparisons were made between pre-treatment and post-treatment.Before treatment,the patients were assessed as moderate NASH by ultrasonography,with a total of 252 cases,accounting for 63.80%.However,after treatment,they were mainly diagnosed as mild NASH,with a total of 311 cases,accounting for 78.73%.Conclusion: Ganzaoning granules could produce obvious effects on NASH.
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Please cite this article as:
ZHANG XiaYan1,PENG Hao2,3,WANG HuaiZhou4,BIAN YanFang1,LU JianYing5,ZHENG GuoYin2,3,. Efficacy of Ganzaoning granules on the patients with nonalcoholic steatohepatitis[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(2): 123-126.
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