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Abstract
Pharmaceutical Care and Research: 2018; 18(2):127-130
DOI: 10.5428/pcar20180212
Efficacy of nifuratel tablets combined with Baofukang suppository in treatment of vaginitis in pregnant women
1. ZHANG Man1(1.Department of Pharmacy,Jingmen Second People’s Hospital of Hubei Province,Hubei Jingmen 448000,China shanzongli886@sina.com)
2. FAN Ye1(1.Department of Pharmacy,Jingmen Second People’s Hospital of Hubei Province,Hubei Jingmen 448000,China )
3. LUO Jia1(1.Department of Pharmacy,Jingmen Second People’s Hospital of Hubei Province,Hubei Jingmen 448000,China )
4. WANG TingTing2(2.Department of Obstetrics and Gynecology,Jingmen Second People’s Hospital of Hubei Province,Hubei Jingmen 448000,China )
5. SU YanLi2(2.Department of Obstetrics and Gynecology,Jingmen Second People’s Hospital of Hubei Province,Hubei Jingmen 448000,China zhiyingli1234@sina.com)
6. XIAO XiaoLin3(3.Department of Pharmacy,Huangshi Maternal and Child Health-Care Hospital,Edong Health Care Group,Hubei Huangshi 435000,China )
ABSTRACT  Objective: To observe efficacy of nifuratel tablets combined with Baofukang suppository in treatment of vaginitis in pregnant women,so as to provide reference for clinical treatment of the disease.Methods: A total of 255 pregnant women with vaginitis were randomly divided into the nifuratel,Baofukang and nifuratel plus Baofukang groups,each consisting of 85 patients.The patients in the nifuratel group received nifuratel tablets at a dosage of 0.2 g three times a day,the patients in the Baofukang group were given 1 Baofukang suppository by vagina every night,and the patients in the nifuratel plus Baofukang group were treated with nifuratel tablets at the same dosage and 1 Baofukang suppository by vagina.After 7 days of treatment,total clinical efficacy,symptom eradication time,recurrent rate and adverse drug reactions (ADRs) were compared between the patients of the 3 groups.Results: Total clinical effective rates for the nifuratel,Baofukang and nifuratel plus Baofukang groups were 72.94%,76.47% and 92.94%,respectively.The eradication time of clinical symptoms were (5.9±1.6),(5.6±1.3) and (3.5±1.2) days,respectively,and the recurrent rates were 16.13%,21.54% and 3.80%.There was no statistical significance,when comparisons were made between the nifuratel group and the Baofukang group (P>0.05).As compared with the nifuratel group and the Baofukang group,the combined group showed the features of high efficacy,short time of symptom disappearance and low recurrence,and statistical significance could be noted(P<0.05).Serious ADRs were not present in all the patients of the 3 groups,and statistical significance was not found in the incidence of ADRs,when comparisons were made between the 3 groups (P>0.05).Conclusion: For patients with pregnancy combined with vaginitis,treatment with nifuratel plus Baofukang suppository could significantly increase clinical efficacy,shorten treatment time,reduce recurrence with good safety.For this reason,it was worth further clinical promotion.
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Please cite this article as:
ZHANG Man1,FAN Ye1,LUO Jia1,WANG TingTing2,SU YanLi2,XIAO XiaoLin3,. Efficacy of nifuratel tablets combined with Baofukang suppository in treatment of vaginitis in pregnant women[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(2): 127-130.
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