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Pharmaceutical Care and Research: 2018; 18(3):161-167
DOI: 10.5428/pcar20180301
Drug-drug interactions associated with direct-acting antiviral agents for hepatitis C
1. JIANG Bo(Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
2. CHEN WanSheng(Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
ABSTRACT  Drug-drug interactions (DDI) associated with direct-acting antiviral agents(DAA) for hepatitis C are generally observed in clinical practice, the mechanisms of which include inhibiting or inducing CYP450 enzyme activity, inhibiting or activating multiple protein transporters and altering plasma protein binding. DDI associated with DAA have two major implications for treatment. First, concomitant medication may affect the exposure level of DAA, resulting in decreased efficacy or increased adverse drug reactions (ADRs). Second, DAA may affect the concentration of concomitant medication, leading to corresponding symptoms or even serious adverse events. There are three scenarios in co-administration of DAA and commonly used drugs such as lipid-regulating drugs, immunosuppressants, antiretroviral drugs and Chinese herbal medicines: (1) drug concentration of DAA or concomitant medication increased by several times (or even dozens of times), leading to serious adverse events and should not be co-administrated; (2) potential clinically significant ADRs which may require additional monitoring, alteration of drug dosage or dosing interval; (3) no clinically significant interaction was expected.
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JIANG Bo,CHEN WanSheng,. Drug-drug interactions associated with direct-acting antiviral agents for hepatitis C[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(3): 161-167.
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