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Pharmaceutical Care and Research: 2018; 18(4):241-246
DOI: 10.5428/pcar20180401
Advances in animal model,pathogenesis and anti-fibrosis treatment of pulmonary fibrosis induced by paraquat
1. LI Sha(Department of Pharmacy,People’s Hospital of Hunan Province,Changsha 410005,China
2. LIU Wen(Department of Pharmacy,People’s Hospital of Hunan Province,Changsha 410005,China
ABSTRACT  Pulmonary fibrosis induced by paraquat is an important factor leading to death of patients, and is also a hot and difficult research topic both at home and abroad. Various studies have shown that the onset time for typical pulmonary fibrosis in the paraquat animal model is approximately 14 to 28 days. However, latest studies have not yet fully elucidated the intoxication mechanism involved. Research findings are mostly focused on the active uptake and accumulation features of paraquat. Furthermore, paraquat itself is an electron receptor that acts on intracellular oxidation reduction reaction and produces large numbers of active free radicals, resulting in disorder of cytokine network, imbalance of protease and dysfunction of mitochondria and accelerating the occurrence and development of fibrosis. At present, the research on anti-fibrosis treatment is mainly focused on herbal medicine, which is now still at the experimental stage and clinical data in this respect remain insufficient. Therefore, this paper gives a comprehensive review on the latest animal model, pathogenesis and treatment of pulmonary fibrosis induced by paraquat, so that solid evidence could be provided for the research and treatment of paraquat toxication.
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LI Sha,LIU Wen,. Advances in animal model,pathogenesis and anti-fibrosis treatment of pulmonary fibrosis induced by paraquat[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(4): 241-246.
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