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Abstract
Pharmaceutical Care and Research: 2018; 18(4):288-291
DOI: 10.5428/pcar20180414
Efficacy and safety of Daying tablets combined with risperidone on cognitive dysfunction of schizophrenia patients
1. ZHANG JianMing(Department of Pharmacy,Shanghai Mental Health Center Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 201108,China 47775195@qq.com)
2. CHEN Yan(Department of Pharmacy,Shanghai Mental Health Center Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 201108,China )
3. LONG Bin(Department of Pharmacy,Shanghai Mental Health Center Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 201108,China )
4. ZHU YuHua(Department of Pharmacy,Shanghai Mental Health Center Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 201108,China )
5. ZHU LiPing(Department of Pharmacy,Shanghai Mental Health Center Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 201108,China zlpjsk@126.com)
6. LU Ying(Department of Pharmacy,Shanghai Mental Health Center Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 201108,China luyingnannan@163.com)
ABSTRACT  Objective:To observe the efficacy and safety of Daying tablets combined with risperidone on cognitive dysfunction of schizophrenia patients.Methods:In the randomized double-blind controlled study,132 schizophrenia patients were randomly divided into the treatment group(n=62) and the control group(n=70). The patients in the treatment group were given Daying tablets 8-10 tablets once,tid.The dosage of risperidone gradually increased from 1 mg/d to 2-4 mg/d in a week,while the patients in the control group were given the same dosage of placebo and risperidone.They were all treated with a treatment course of 12 weeks.The cognitive function of the patients was evaluated with a repeatable battery for the assessment of neuropsychological status(RBANS) before treatment and at the 12th week.Clinical efficacy and the safety were evaluated with positive and negative syndrome scale(PANSS) and treatment emergent symptom scale(TESS) before admission into group and at the 2nd,4th,8th and 12th week after treatment,respectively.Results: For the treatment group,RBANS scores increased more significantly,while the scores of PANSS scale decreased,and the incidence of constipation,dry mouth and weight gain was significantly lower than that of the control group (P<0.05). However,the incidence of diarrhea in the treatment group was obviously higher,as compared with the control group (P<0.05).Conclusion:Daying tablets and risperidone could improve cognitive dysfunction of schizophrenia patients and could intensify the effect on the alleviation of mental symptoms,with good safety.
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Please cite this article as:
ZHANG JianMing,CHEN Yan,LONG Bin,ZHU YuHua,ZHU LiPing,LU Ying,. Efficacy and safety of Daying tablets combined with risperidone on cognitive dysfunction of schizophrenia patients[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(4): 288-291.
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