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Abstract
Pharmaceutical Care and Research: 2018; 18(5):347-350
DOI: DOI:10.5428/pcar20180508
Efficacy of vitamin D combined with ω-3 fatty acid in treatment of children with autism spectrum disorder
1. FANG Le(Department of Children Rehabilitation,Maternal and Child Health-Care Hospital of Nanshan District,Shenzhen,Shenzhen Guangdong 518000,China 0826xiaozhiyao@sina.com)
2. JIANG XueMing(Department of Children Rehabilitation,Maternal and Child Health-Care Hospital of Nanshan District,Shenzhen,Shenzhen Guangdong 518000,China )
3. HUANG YanKe(Department of Children Rehabilitation,Maternal and Child Health-Care Hospital of Nanshan District,Shenzhen,Shenzhen Guangdong 518000,China )
4. SUN YanXiang(Department of Children Rehabilitation,Maternal and Child Health-Care Hospital of Nanshan District,Shenzhen,Shenzhen Guangdong 518000,China )
5. XIE YuFang(Department of Children Rehabilitation,Maternal and Child Health-Care Hospital of Nanshan District,Shenzhen,Shenzhen Guangdong 518000,China )
6. WANG Lu(Department of Children Rehabilitation,Maternal and Child Health-Care Hospital of Nanshan District,Shenzhen,Shenzhen Guangdong 518000,China )
ABSTRACT  Objective: To observe the efficacy of vitamin D combined with ω-3 fatty acid in treatment of children with autism spectrum disorder(ASD). Methods: Forty-eight children aged 5 to 12 years old who were newly diagnosed as ASD were enrolled for the randomized double-blind clinical trial.All the patients were randomly divided into 4 groups,each consisting of 12 patients.The patients in the control group received placebo, while the patients in the vitamin D group received vitamin D at a dosage of 800 U/d, and the patients in the ω-3 fatty acid group received ω-3 fatty acid at a dosage of 900 mg/d.The patients in the combined treatment group received vitamin D (800 U/d) and ω-3 fatty acid (900 mg/d).During treatment,all the patients were trained by using Treatment and Education of Autistic and related Communication-handicapped Children(TEACCH) intervention approach in the hospital,4 hours a day,5 days a week.Clinical symptoms were evaluated by Childhood Autism Rating Scale(CARS) 12 months after treatment.Results: After 12 months of treatment,the scores of CARS significantly decreased in the vitamin D group and the combined treatment group compared with those of the control group (P<0.05).Compared to the vitamin D group,the scores of visual and auditory response in the combined treatment group dropped more significantly(P<0.05). Compared to the ω-3 fatty acid group,the scores of anxiety of the combined treatment group decreased more significantly(P<0.05).Conclusion: Vitamin D or vitamin D combined with ω-3 fatty acid supplemented with TEACCH intervention approach could improve symptoms of children with ASD.Vitamin D plus ω-3 fatty acid could be an effective adjuvant treatment for children with ASD.
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Please cite this article as:
FANG Le,JIANG XueMing,HUANG YanKe,SUN YanXiang,XIE YuFang,WANG Lu,. Efficacy of vitamin D combined with ω-3 fatty acid in treatment of children with autism spectrum disorder[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(5): 347-350.
References:
1. Spillers J L,Sensui L M,Linton K F.Concerns about identity and services among people with autism and Asperger’s regarding DSM-5 changes[J]. J Soc Work Disabil Rehabil, 2014, 13(3):247-260.
2. Patrick R P,Ames B N.Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism[J].FASEB J,2014,28(6):2398-2413.
3. JIA FeiYong,WANG Bing,SHAN Ling,et al.Core symptoms of autism improved after vitamin D supplementation[J].Pediatrics,2015,135(1):e196-e198.
4. Amminger G P, Berger G E, Schfer M R,et al.Omega-3 fatty acids supplementation in children with autism: a double-blind randomized, placebo-controlled pilot study[J].Biol Psychiatry,2007, 61(4):551-553.
5. Saad K, Abdel-Rahman A A, Elserogy Y M,et al.Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children[J].Nutr Neurosci,2016,19(8):346-351.
6. Cannell J J, Grant W B. What is the role of vitamin D in autism?[J].Dermatoendocrinol,2013,5(1):199-204.
7. Lee V, Rekhi E, Hoh Kam J,et al.Vitamin D rejuvenates aging eyes by reducing inflammation, clearing amyloid beta and improving visual function[J].Neurobiol Aging,2012,33(10):2382-2389.
8. Armstrong D J,Meenagh G K,Bickle I,et al.Vitamin D deficiency is associated with anxiety and depression in fibromyalgia[J]. Clin Rheumatol, 2007, 26(4):551-554.
9. LIANG You,SHEN Jian,Lü YongXue.Effect of vitamin D supplementation on small fontanel pediatric growth of head circumference and Bayley intelligence test results[J].Chin Rural Health Serv Adm,2014,34(7):857-859.In Chinese with English abstract.
10. Kiecolt-Glaser J K,Belury M A,Andridge R,et al.Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial[J].Brain Behav Immun,2011,25(8):1725-1734.
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