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Pharmaceutical Care and Research: 2018; 18(5):351-355
DOI: DOI:10.5428/pcar20180509
Cross-reactivity induced by vancomycin and teicoplanin: a case report and literature review
1. ZHENG GuanHao1(1.Department of Pharmacy,Xiaolan People’s Hospital Affiliated to Southern Medical University,Zhongshan Guangdong 528400,China
2. CAO Li2(2.Department of Pharmacy,Zhongshan People’s Hospital of Guangdong Province,Zhongshan Guangdong 528400,China )
3. CHEN ErZhen3(3.Emergency Intensive Care Unit,Ruijin Hospital Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China )
4. HE Juan4(4.Department of Pharmacy,Ruijin Hospital Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China
ABSTRACT  Objective: To investigate symptoms, incidence and treatment of cross-reactivity induced by vancomycin and teicoplanin, so as to arouse the attention of physicians and clinical pharmacists for rare allergic reactions and promote rational use of drugs clinically. Methods: Presented in the paper was a case of cross-reactivity induced by vancomycin and teicoplanin in the treatment of severe acute pancreatitis (SAP). A discussion was made on the mechanism and epidemiology of such allergic reactions, and alternative therapeutic regimens and desensitization protocols were also proposed, when faced with such allergic reactions. Results: Case reports of cross-reactivity induced by vancomycin and teicoplanin were rarely seen. Retrospective study revealed that about 10% of the patients with allergic reactions after application of vancomycin might have allergic reactions to teicoplanin. Conclusion: Vancomycin and teicoplanin might induce cross allergic reactions. Once adverse drug reactions occurr, the drugs applied should be immediately withdrawn and appropriate alternative antibiotics should be used. If necessary, vancomycin desensitization could be a feasible option for continuous treatment.
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ZHENG GuanHao1,CAO Li2,CHEN ErZhen3,HE Juan4,. Cross-reactivity induced by vancomycin and teicoplanin: a case report and literature review[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(5): 351-355.
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