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Abstract
Pharmaceutical Care and Research: 2018; 18(5):356-359
DOI: DOI:10.5428/pcar20180510
Simultaneous determination of concentrations of sulpiride,tiapride and amisulpride in human serum by HPLC method
1. CHEN Ying1(1.Department of Drugs and Equipment,No. 102 Hospital of PLA,Changzhou Jiangsu 213003, China chensiyu1123@163.com)
2. LI Yan1(1.Department of Drugs and Equipment,No. 102 Hospital of PLA,Changzhou Jiangsu 213003, China )
3. TAN XingQi1(1.Department of Drugs and Equipment,No. 102 Hospital of PLA,Changzhou Jiangsu 213003, China )
4. QU FaLin1(1.Department of Drugs and Equipment,No. 102 Hospital of PLA,Changzhou Jiangsu 213003, China qufalin@163.com)
5. ZHOU Zhou2(2.Teaching and Research Section of Pharmaceutical Analysis,Hanlin College,Nanjing University of Chinese Medicine,Taizhou Jiangsu 225300,China )
6. JIN Ting1(1.Department of Drugs and Equipment,No. 102 Hospital of PLA,Changzhou Jiangsu 213003, China )
ABSTRACT  Objective: To establish a HPLC method for simultaneous determination of concentrations of sulpiride, tiapride and amisulpride in human serum.Methods: ZE Month Crest ODS-L column(150 mm×4.6 mm,5 μm) was employed with the mobile phase of 30 mmol/L potassium dihydrogen phosphate(pH 7.5) -methanol-acetonitrile(77∶15∶8) at a flow rate of 1.0 ml/min. Column temperature was 30 ℃, and detection wavelength was 230 nm.Blood samples were extracted with ethyl acetate as extracting solvent.Results: Serum trough concentrations of sulpiride, tiapride and amisulpride were within the range of 25-2000 ng/ml with good linearity. The regression equations were: Y=0.001 7 c+0.023 0 (r=0.999 0), Y=0.001 9 c+0.009 2 (r=0.999 1), Y=0.003 8 c-0.024 2 (r=0.999 0), respectively. Recovery rates, intra-day and inter-day variations all conformed to the specified detection methods.Conclusion: The method is sensitive,accurate,simple and fast,which could be used for clinical drug monitoring and pharmacokinetics studies of sulpiride,tiapride and amisulpride.
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Please cite this article as:
CHEN Ying1,LI Yan1,TAN XingQi1,QU FaLin1,ZHOU Zhou2,JIN Ting1,. Simultaneous determination of concentrations of sulpiride,tiapride and amisulpride in human serum by HPLC method[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(5): 356-359.
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