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Abstract
Pharmaceutical Care and Research: 2018; 18(5):360-363
DOI: DOI:10.5428/pcar20180511
Simultaneous determination of the contents of menthol and phenol in calamine menthol lotion by GC method
1. LI Sha1(1.Faculty of Pharmacy,School of Medicine,Hunan Normal University,Changsha 410015,China musha1220@outlook.com)
2. 2(2.Department of Pharmacy,People’s Hospital of Hunan Province,Changsha 410005,China musha1220@outlook.com)
3. YAN Xiao2(2.Department of Pharmacy,People’s Hospital of Hunan Province,Changsha 410005,China )
4. WU YangKe1(1.Faculty of Pharmacy,School of Medicine,Hunan Normal University,Changsha 410015,China )
5. 2(2.Department of Pharmacy,People’s Hospital of Hunan Province,Changsha 410005,China )
6. DAI YingChun2(2.Department of Pharmacy,People’s Hospital of Hunan Province,Changsha 410005,China )
7. LIU XiangLi3(3.Faculty of Pharmacy,Changsha Medical College,Changsha 410219,China )
8. LIU Wen2(2.Department of Pharmacy,People’s Hospital of Hunan Province,Changsha 410005,China )
ABSTRACT  Objective: To establish a gas chromatography(GC) method for simultaneous determination of the contents of menthol and phenol in calamine menthol lotion,in order to provide a reliable method for quality control of calamine menthol lotion.Methods: Camphor was used as the internal standard and the solvent was 95% ethanol.Separation was carried out on an Agilent DB-624 capillary column (30 m×320 μm,1.8 μm) with nitrogen as the carrier gas.The column temperature was 140 ℃ and the injection port and flame ionization detector temperatures were 240 ℃ and 250 ℃,respectively.The split ratio was 10∶1 and the injection volume was 1 μl.Results:The contents of menthol and phenol in the ranges of 69.97-129.95 μg/ml (r=0999 1) and 141.75-263.25 μg/ml (r=0.999 2) showed a good linear relationship with the peak area of internal standard. The average recovery rates of menthol and phenol were (103.35±1.14)% and (103.16±0.95)%(n=9),respectively.Conclusion:The established method is simple, feasible and reproducible, and could be used for quality control of calamine menthol lotion.
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Please cite this article as:
LI Sha1,2,YAN Xiao2,WU YangKe1,2,DAI YingChun2,LIU XiangLi3,LIU Wen2,. Simultaneous determination of the contents of menthol and phenol in calamine menthol lotion by GC method[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(5): 360-363.
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