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Pharmaceutical Care and Research: 2018; 18(5):364-367
DOI: DOI:10.5428/pcar20180512
Quality control of Biyuanjing capsules
1. CHENG YanQin1(1.Department of Pharmacy,No.401 Hospital of PLA,Qingdao Shandong 266071,China
2. CHEN YanShen2(2.School of Pharmacy,Dalian Medical University,Dalian Liaoning 116044,China )
3. LI MingChun1(1.Department of Pharmacy,No.401 Hospital of PLA,Qingdao Shandong 266071,China
ABSTRACT  Objective: To establish quality control methods of Biyuanjing capsules.Methods:Forsythiae Fructus,Chrysanthemi Indici Flos,Magnoliae Flos and Angelicae Dahuricae Radix in Biyuanjing capsules were identified by thin layer chromatography(TLC) method.Contents of mononoside in Chrysanthemi Indici Flos,imperatorin in Notopterygii Rhizoma Et Radix and Angelicae Dahuricae Radix were determined by HPLC method.Agilent SB-C18 column(250 mm×4.6 mm,5 μm) was used with the mobile phase consisting of acetonitrile(A)-water(B),gradient elution(0-8 min 27% phase A,8-10 min 27%-55%A,10-30 min 55%A). The detection wave-length was 310 nm and the column temperature was 20 ℃.Results:The spots in the TLC photograms were clear.The test substances were well separated,without any interference from others.The contents of mononoside and imperatorin were in good linear within the ranges of 0.28-2.84 μg,0.069-0.69 μg(r=0.999 9,r=1.000 0),respectively.Conclusion:This method is simple and reproducible,and could be used for the quality control of Biyuanjing capsules.
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Please cite this article as:
CHENG YanQin1,CHEN YanShen2,LI MingChun1,. Quality control of Biyuanjing capsules[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(5): 364-367.
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