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Abstract
Pharmaceutical Care and Research: 2018; 18(5):377-380
DOI: DOI:10.5428/pcar20180516
Influence of packaging temperatures and storage time on migration amount of plasticizer in the packaging material of Chinese herbal decoction
1. CHENG DongHai1(1.Department of Pharmacy,Tongji Hospital Affiliated to Tongji University,Shanghai 200065,China aqct@163.com)
2. ZHANG XiaYan2(2.Department of Pharmacy,Changhai Hospital,Second Military Medical University,Shanghai 200433,China 617882699@qq.com)
3. YIN XueQin2(2.Department of Pharmacy,Changhai Hospital,Second Military Medical University,Shanghai 200433,China )
4. BIAN YanFang2(2.Department of Pharmacy,Changhai Hospital,Second Military Medical University,Shanghai 200433,China )
5. LU CuiYan3(3.Department of Pharmacy, Traditional Chinese Medicine Hospital of Putuo District of Shanghai,Shanghai 200062,China )
ABSTRACT  Objective: To investigate the migration amount of plasticizer di-(2-ethylhexyl) phthalate(DEHP) in the packaging material of Chinese herbal decoction at different packaging temperatures and storage time.Methods: The concentration of DEHP was determined by HPLC method,with Cosmosil-C18 column(150 mm×4.6 mm,5 μm),methanol-acetonitrile-water(10∶90∶0.5) as the mobile phase at a flow rate of 1.0 ml/min.The column temperature was 30 ℃ and the detection wavelength was 224 nm.The repeatability,precision and recovery rates of DEHP were determined.The Chinese herbal decoction was packaged at 40,60,80 and 100 ℃, respectively,and the contents of DEHP were determined after storage for 1,3,7 and 14 days.Results: DEHP was in good linearity with its peak area within the range of 0.266-8.5 mg/L(r=0.999 5).The recovery rate was (99.86±0.84)%(n=6).When the decoction was stored for 1,3,7,14 days,the migration amounts of DEPH at different temperatures were: (18.00±0.09),(21.00±006),(50.00±0.24) and (127.00±0.13) μg/kg at 40 ℃;(36.00±0.20),(34.00±0.19),(57.00±0.13) and (102.00±0.37) μg/kg at 60 ℃;(43.00±0.25),(44.00±012),(45.00±0.14) and (43.00±0.23) μg/kg at 80 ℃;(45.00±0.11),(44.00±0.14),(31.00±0.20) and (31.00±0.07) μg/kg at 100 ℃,respectively.When the Chinese herbal decoction was packaged at 40-100 ℃ and stored for 1-14 days,the intake amount of DEHP was 7.2-50.8 μg/d calculated by 200 ml per pack and 2 packs per day.Conclusion: The optimal packaging temperature of Chinese herbal decoction is 80 ℃.
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Please cite this article as:
CHENG DongHai1,ZHANG XiaYan2,YIN XueQin2,BIAN YanFang2,LU CuiYan3,. Influence of packaging temperatures and storage time on migration amount of plasticizer in the packaging material of Chinese herbal decoction[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(5): 377-380.
References:
1. ZHANG Lu,ZHANG TengLing,ZONG Teng,et al.Effect of di-(2-ethylhexyl) phthalate exposure on placental development in pregnant mice[J].J South Med Univ,2016,36(4):467-471.In Chinese with English abstract.
2. XU Yi,XUE Shan,HE ZhiFei,et al.Toxicity characteristics and migration studies on plasticizer DEHP in food packaging[J].Food Ind Sci Technol,2013,34(21):385-389.In Chinese with English abstract.
3. ZHAO Jing,GUO Xing,WU JiaZi,et al.Effect of DEHP on the expression of JAZF1 mRNA and TR4 protein in mouse spermatocyte(GC-2spd) cells[J].Acta Univ Med Anhui,2017,52(6):847-849,854.In Chinese with English abstract.
4. XU XiaoHong,SHEN Chao,ZHOU Yi,et al.Research advances in developmental and neurological toxicity of di-(2-ethylhexyl) phthalate[J].J Zhejiang Normal Univ(Nat Sci),2013,36(2):209-212,216.In Chinese with English abstract.
5. LI Na.Studies on reproductive toxicity and related mechanism of DEHP and its metabolite MEHP in female rats[D].Changchun:Jilin University,2013.In Chinese with English abstract.
6. Ministry of Health of the People’s Republic of China,State Standardization Administration of China.GB 9685-2008 hygienic standards for uses of additives in food containers and packaging materials[S].Beijing:China Standard Publishing House,2008.In Chinese.
7. MENG XueZheng,NIU GuiLong,ZENG Ming,et al.Occurrence,hazard and biodegradation of di-(2-ethylhexyl) phthalate in environment[J].Ecol Environ Sci,2014,23(8):1384-1389.In Chinese with English abstract.
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