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Abstract
Pharmaceutical Care and Research: 2018; 18(5):385-388
DOI: DOI:10.5428/pcar20180518
Pareto diagram analysis of 128 cases of serious adverse drug reactions from 2013 to 2016 in Shanghai First Hospital Affiliated to Shanghai Jiaotong University
1. LIU Hua(Deptartment of Clinical Pharmacy, Shanghai First Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200080, China liuhuafj2006@126.com)
2. ZHOU JiaChun(Deptartment of Clinical Pharmacy, Shanghai First Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200080, China acechampion@126.com)
3. FAN GuoRong(Deptartment of Clinical Pharmacy, Shanghai First Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200080, China guorfan@163.com)
ABSTRACT  Objective: To analyze the features, regular patterns, high risk factors and preventive measures concerning the occurrence of serious adverse drug reactions (SADRs) in the Shanghai First Hospital Affiliated to Shanghai Jiaotong University, so as to provide reference for clinical pharmacovigilance and safe and rational medication. Methods: 128 cases of SADRs in the hospital reported to the National Drug Adverse Reaction Monitoring System from January 2013 to October 2016 were recruited for the study, and related factors were analyzed by Pareto diagram. Results: Of the 128 cases of SADRs, 68 were male cases and 60 were female cases, and 20 were new SADR cases and 7 were unimproved cases. Results indicated that the main drug categories that caused SADRs were cardiovascular drugs, antimicrobials, antitumor drugs and Chinese herbal drugs. For cardiovascular drugs, aspirin enteric-coated tablets had the highest rate of SADR, and for antimicrobials, there were 6 cases of wrong drug application and dosage, affecting organs and or systems. Clinical manifestations of SADRs mainly reflected in liver and the gallbladder system, the blood system, the digest system, the cardiovascular system and even caused systemic damage, and most commonly seen symptoms were the elevated level of tansaminase and the suppression of bone marrow. Conclusion: Clinical medical personnel should heighten awareness of SADRs and reduce the rate of SADRs induced by wrong medication to lowest possible level. Patients with chronic diseases should have routine medical checks, so that incidence of SADRs could be avoided eventually. In the meantime, the hospital administration should conduct training related to pharmacovigilance at an irregular interval. Main attention should be paid to those drugs with high rate of SADRs and new ADRs, and positive measures should be taken, once ADRs occur.
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Please cite this article as:
LIU Hua,ZHOU JiaChun,FAN GuoRong,. Pareto diagram analysis of 128 cases of serious adverse drug reactions from 2013 to 2016 in Shanghai First Hospital Affiliated to Shanghai Jiaotong University[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(5): 385-388.
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