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Pharmaceutical Care and Research: 2018; 18(6):401-405
DOI: 10.5428/pcar20180601
Advances in biotherapy of diabetic nephropathy
1. SHEN YiLan(Department of Nephrology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China
2. DING Tao(Department of Nephrology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China )
3. MEI XiaoBin(Department of Nephrology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China
ABSTRACT  Diabetic nephropathy(DN),one of the causes of end-stage renal disease,is closely related to increased incidence of cardiovascular morbidity and mortality.Current treatment approaches of DN include strict control of blood glucose,lowering blood pressure and reducing albuminuria by renal-angiotensin-aldosterone system blockers.However,these are only symptomatic treatment,and effective treatment of DN is still not available.This review explores the role and clinical research advances of some biomolecules in the pathogenesis of DN,such as glucagon-like peptide-1(GLP-1),integrin αVβ3,endothelin A(ETA),chemokine receptor 2(CCR2),etc.
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SHEN YiLan,DING Tao,MEI XiaoBin,. Advances in biotherapy of diabetic nephropathy[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(6): 401-405.
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