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Abstract
Pharmaceutical Care and Research: 2018; 18(6):410-414
DOI: 10.5428/pcar20180604
Efficacy of total glucosides of Radix paeoniae alba in the treatment of low risk idiopathic membranous nephropathy and the value of serum anti-phospholipase A2 receptor antibodies
1. TANG Qi1(1.Department of Nephrology,Zhabei Central Hospital of Jing’an District,Shanghai 200070,China tangqimed@aliyun.com)
2. ZHANG LiMing1(1.Department of Nephrology,Zhabei Central Hospital of Jing’an District,Shanghai 200070,China zlm198291@163.com)
3. WU BiBo1(1.Department of Nephrology,Zhabei Central Hospital of Jing’an District,Shanghai 200070,China )
4. LI Lin2(2.Department of Nephrology,Changzheng Hospital,Second Military Medical University,Kidney Disease Institute of PLA,Shanghai 200003,China )
5. YU Hua1(1.Department of Nephrology,Zhabei Central Hospital of Jing’an District,Shanghai 200070,China )
6. LIANG CongDie1(1.Department of Nephrology,Zhabei Central Hospital of Jing’an District,Shanghai 200070,China )
ABSTRACT  Objective: To observe the efficacy of total glucosides of Radix paeoniae alba(TGP) in the treatment of patients with low risk idiopathic membranous nephropathy (IMN),and to evaluate the value of serum anti-phospholipase A2 receptor(PLA2R) antibodies in the treatment.Methods: Sixty-five low risk IMN patients with 24 h urinary protein excretion <4 g and normal renal function were divided into four groups according to the detection results of serum anti-PLA2R antibodies: the anti-PLA2R antibodies positive group (the treatment group A,n=22),the anti-PLA2R antibodies positive control group (the control group B,n=22),the anti-PLA2R antibodies negative group (the treatment group C,n=10),and the anti-PLA2R antibodies negative group (the control group D,n=11).The patients in the two control groups received conservative treatment and the patients in the two treatment groups were supplemented with 600 mg TGP three times a day for a succession of 12 months on the basis of conservative treatment.24-h urinary protein,the ratio of urinary albumin to creatinine(ACR),serum albumin(SAlb) and serum creatinine(SCr) and serum anti-PLA2R antibodies were detected 6 and 12 months after treatment.Then,efficacy and safety were evaluated.Results: Of the 65 patients,there were 44 patients with positive serum anti-PLA2R antibodies, with a positive rate of 67.7%.Compared with the baseline of the same group and those of the 2 control groups detected within the same time span,the 24-h urinary protein and ACR of the patients in group C after 6-month and 12-month treatment,and the same data of the patients in group A after 12-month treatment,all decreased significantly (P<0.05),while the level of SAlb elevated significantly (P<0.05).The decreased rate of 24-h urinary protein and ACR of the patients in group C after 12-month treatment and the increased rate of SAlb were more significant,as compared with those of group A (P<0.05).After 12 months of treatment,statistical differences could be noted in effective rate,when comparisons were made between the 2 treatment groups (group A and group C) and 2 control groups (group B and group D) (66.7% vs 31.0%,P<0.01).Conclusion:TGP could effectively reduce proteinuria level in patients with low risk IMN and improve clinical efficacy.Compared with the anti-PLA2R antibodies positive group,the levels of proteinuria and SAlb in the patients of the antibodies negative group improved more significantly.The detection of serum anti-PLA2R antibodies is helpful for the treatment of patients with low risk IMN.
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Please cite this article as:
TANG Qi1,ZHANG LiMing1,WU BiBo1,LI Lin2,YU Hua1,LIANG CongDie1,. Efficacy of total glucosides of Radix paeoniae alba in the treatment of low risk idiopathic membranous nephropathy and the value of serum anti-phospholipase A2 receptor antibodies[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(6): 410-414.
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