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Abstract
Pharmaceutical Care and Research: 2018; 18(6):429-433
DOI: 10.5428/pcar20180609
Effects of celastrol on serum bile acid metabolite profiling in mice with inflammatory bowel disease
1. QI YunPeng1(1.Teaching and Research Section of Pharmaceutical Analysis,School of Pharmacy,Fudan University,Shanghai 201203,China qiyunpeng@hotmail.com)
2. 2(2.Teaching and Research Section of Pharmaceutical Analysis,School of Pharmacy,Second Military Medical University,Shanghai 200433,China qiyunpeng@hotmail.com)
3. ZHANG Tian2(2.Teaching and Research Section of Pharmaceutical Analysis,School of Pharmacy,Second Military Medical University,Shanghai 200433,China )
4. WANG RenPing2(2.Teaching and Research Section of Pharmaceutical Analysis,School of Pharmacy,Second Military Medical University,Shanghai 200433,China )
5. SONG YunLong2(2.Teaching and Research Section of Pharmaceutical Analysis,School of Pharmacy,Second Military Medical University,Shanghai 200433,China )
6. LU Feng2(2.Teaching and Research Section of Pharmaceutical Analysis,School of Pharmacy,Second Military Medical University,Shanghai 200433,China )
7. DUAN GengLi1(1.Teaching and Research Section of Pharmaceutical Analysis,School of Pharmacy,Fudan University,Shanghai 201203,China glduan@shmu.edu.cn)
ABSTRACT  Objective: To explore the potential mechanism of celastrol in inflammatory bowel disease (IBD) by investigating its effects on the serum bile acid metabolite profiling of IBD mice.Methods: The IBD mice model was developed by using dextran sulfate sodium.The relative concentrations of 22 bile acids in the serum of IBD mice were determined by using UPLC-MS/MS. Results: In IBD mice,the relative concentrations of free primary bile acids,such as cholic acid (CA) and chenodeoxycholic acid (CDCA) were significantly increased,while the levels of several binding primary bile acids,such as taurocholic acid (TCA) and taurodeoxycholic acid (TDCA) were obviously decreased,and the levels of some secondary bile acids,such as lithocholic acid (LCA) were also significantly reduced.After administration of celastrol,the metabolic changes of the above primary and secondary bile acids in the serum of the IBD mice recovered to a certain extent.Conclusion:Celastrol might regulate the liver function and metabolic enzyme expression of the IBD mice,intervene the binding process of primary bile acids,thus improve the symptoms of the IBD mice.
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Please cite this article as:
QI YunPeng1,2,ZHANG Tian2,WANG RenPing2,SONG YunLong2,LU Feng2,DUAN GengLi1,. Effects of celastrol on serum bile acid metabolite profiling in mice with inflammatory bowel disease[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(6): 429-433.
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