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Abstract
Pharmaceutical Care and Research: 2018; 18(6):452-455
DOI: 10.5428/pcar20180615
Application of self-made lung perfusate in ex vivo lung perfusion in pigs
1. PAN Yan1(1.Department of Pharmacy,Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200030,China sispan@126.com)
2. GU Chang2(2.Department of Thoracic Surgery,Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200030,China )
3. YE Bo2(2.Department of Thoracic Surgery,Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200030,China )
4. ZHU Jun1(1.Department of Pharmacy,Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200030,China )
5. SUN YiFeng2(2.Department of Thoracic Surgery,Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200030,China sunyifeng1121@163.com)
6. WANG WeiMin3(3.Department of Pulmonary Function,Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200030,China 13817680693@139.com)
ABSTRACT  Objective: To investigate the application of self-made lung perfusate in ex vivo lung perfusion(EVLP) in pigs.Methods:The donor lungs were obtained from 7 pigs for EVLP.During EVLP,the pH value,concentrations of electrolytes,osmotic pressure of the perfusate were measured every hour,while the pulmonary function indexes were recorded simultaneously and the artery-vein oxygen partial pressure difference(ΔPO2),pulmonary vascular resistance(PVR) and oxygenation index were calculated to evaluate the quality of the donor lungs.Results:The pH value,concentrations of electrolytes,osmotic pressure of the perfusate remained stable during the 6-h EVLP.The ΔPO2 and oxygenation index reached peak at hour 4 of EVLP,while no significant increase in pulmonary vascular resistance (PVR) could be seen.Conclusion:The self-made perfusate could be used for EVLP in pigs and it had certain protective and repairing effects for donor lungs.
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Please cite this article as:
PAN Yan1,GU Chang2,YE Bo2,ZHU Jun1,SUN YiFeng2,WANG WeiMin3,. Application of self-made lung perfusate in ex vivo lung perfusion in pigs[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2018; 18(6): 452-455.
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