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Abstract
Pharmaceutical Care and Research: 2019; 19(2):106-110
DOI: 10.5428/pcar20190207
Preclinical research progress of ligustilide
1. YAO Songyun1(1.Teaching and Research Section of Organic Chemistry,School of Pharmacy,Navy Military Medical University,Shanghai 200433,China ysy2010110@163.com)
2. ZHANG Kaixia1(1.Teaching and Research Section of Organic Chemistry,School of Pharmacy,Navy Military Medical University,Shanghai 200433,China )
3. 2( 2.School of Pharmacy,Yantai University,Shandong Yantai 264005,China )
4. MA Qiang3( 3.Engineering Research Center of Modern Preparation Technology of Traditional Chinese Materia Medica,Ministry of Education,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China )
5. JIN Yongsheng1(1.Teaching and Research Section of Organic Chemistry,School of Pharmacy,Navy Military Medical University,Shanghai 200433,China ysjinsmmu@163.com)
ABSTRACT  In this paper,related literature on the plant origin,physicochemical properties,pharmacological effects and pharmacokinetics of ligustilide were analyzed and summarized. It was found that the pharmacological effects of ligustilide were extensive,including the effects on atherosclerosis,analgesic,anti-inflammatory,senile dementia,cerebral ischemia and other related models. In addition,it had the effects of anti-tumor,anti-lipid peroxidation,enhancement of microcirculation,and so on. In terms of pharmacokinetics,ligustilide conformed to the two-compartment model. The main effector organs were the lungs,heart and brain. The main eliminating organs were the liver,spleen and kidney. It had the characteristics of rapid absorption and slow elimination,but with low bioavailability when administered by gavage.
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Please cite this article as:
YAO Songyun1,ZHANG Kaixia1,2,MA Qiang3,JIN Yongsheng1,. Preclinical research progress of ligustilide[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2019; 19(2): 106-110.
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