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Pharmaceutical Care and Research: 2019; 19(2):121-124
DOI: 10.5428/pcar20190211
Research advances in drug delivery system of cabazitaxel for treatment of patients with prostate cancer
1. WAN Zhong1(1.Department of Urology,Changzheng Hospital,Navy Military Medical University,Shanghai 200003,China
2. SUN Zhiguo2( 2.Teaching and Research Section of Pharmaceutics,School of Pharmacy,Navy Military Medical University,Shanghai 200433,China )
3. LU Ying2( 2.Teaching and Research Section of Pharmaceutics,School of Pharmacy,Navy Military Medical University,Shanghai 200433,China )
4. WANG Linhui1(1.Department of Urology,Changzheng Hospital,Navy Military Medical University,Shanghai 200003,China
ABSTRACT  Cabazitaxel is a new taxane-based anti-tumor drug,which has a significant effect on hormone refractory metastatic prostate cancer patients who are ineffective to docetaxel. Although cabazitaxel is used as a second-line clinical drug,it has great application potential due to its low adhesion to P-glycoprotein and good pharmacokinetic characteristics. In recent years,researchers are paying more attention to it. Based on the research progress achieved both at home and abroad and with the pharmacological effects and adverse drug reactions as the starting point,a comprehensive review was made in the drug delivery system of cabazitaxel for treatment of prostate cancer.
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WAN Zhong1,SUN Zhiguo2,LU Ying2,WANG Linhui1,. Research advances in drug delivery system of cabazitaxel for treatment of patients with prostate cancer[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2019; 19(2): 121-124.
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