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Pharmaceutical Care and Research: 2019; 19(3):161-165
DOI: 10.5428/pcar20190301
Research progress in tumor-associated macrophage drug targeted delivery systems
1. WANG Xiaoyu1(1.Departmemt of Pharmacy,General Hospital of Western Theater Command,Chengdu 610036,China
2. GAO Shen2(2.Department of Pharmacy,Changhai Hospital,Navy Military Medical University,Shanghai 200433,China
ABSTRACT  Tumor-associated macrophage (TAM) is abundantly distributed in tumor micro-environment,which is closely related to tumor cell growth and metastasis,immunosuppression and neovascularization.Tumor-targeted therapy strategy that focuses on TAM is a hot topic in recent years.In this paper,the factors influencing the targeted delivery of TAM by nanoparticles,the results of TAM as a living cell target for tumor tissue delivery and TAM polarity transformation were reviewed,and prospect for future development was forecasted.
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WANG Xiaoyu1,GAO Shen2,. Research progress in tumor-associated macrophage drug targeted delivery systems[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2019; 19(3): 161-165.
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