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Pharmaceutical Care and Research: 2019; 19(3):166-171
DOI: 10.5428/pcar20190303
Research progress in clinical treatment of oral anticoagulants
1. MENG Lu1(1.Graduate School,Hebei Medical University,Shijiazhuang 050017,China
2. DING Congyang1(1.Graduate School,Hebei Medical University,Shijiazhuang 050017,China )
3. AN Jing1(1.Graduate School,Hebei Medical University,Shijiazhuang 050017,China )
4. 2( 2.Department of Pharmacy,Hebei General Hospital,Shijiazhuang 050051,China )
5. LI Yajing1(1.Graduate School,Hebei Medical University,Shijiazhuang 050017,China )
6. LI Ying2( 2.Department of Pharmacy,Hebei General Hospital,Shijiazhuang 050051,China )
7. DONG Zhanjun1(1.Graduate School,Hebei Medical University,Shijiazhuang 050017,China
8. 2( 2.Department of Pharmacy,Hebei General Hospital,Shijiazhuang 050051,China )
ABSTRACT   In recent years,with the increasing incidence and mortality of thromboembolic diseases,anticoagulants have important clinical significance and practical value to the prevention and treatment of thromboembolic diseases.Oral anticoagulants are mainly divided into traditional oral drugs and new oral anticoagulants.Clinically,warfarin is commonly used as a traditional oral anticoagulant.However,its treatment window is narrow,dosage needs constantly adjustment,and the interactions between warfarin and other drugs and food bring about inconvenience in clinical use.New oral anticoagulants,such as rivaroxaban,apisaban,edoxaban,betroxaban and dabigatran etexilate,are superior to warfarin,because of the advantages of no frequent dosage adjustment,no routine monitoring of coagulation function and low bleeding rate in the treatment of thrombotic diseases.Besides,their safety and efficacy are by no means inferior to warfarin.This article reviews related literature on the progress of drug therapy for thromboembolic diseases published at home and abroad in recent years,and provides references for the standardized use of oral anticoagulants in clinical practice.
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MENG Lu1,DING Congyang1,AN Jing1,2,LI Yajing1,LI Ying2,DONG Zhanjun1,2,. Research progress in clinical treatment of oral anticoagulants[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2019; 19(3): 166-171.
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