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Abstract
Pharmaceutical Care and Research: 2019; 19(3):180-184
DOI: 10.5428/pcar20190306
Relationship between serum anti-phospholipase A2 receptor antibodies and immunotherapy of the patients with idiopathic membranous nephropathy
1. TANG Qi1(1.Department of Nephrology,Zhabei Central Hospital of Jing’an District,Shanghai 200070,China tangqimed@aliyun.com)
2. WU Bibo1(1.Department of Nephrology,Zhabei Central Hospital of Jing’an District,Shanghai 200070,China )
3. LI Lin2(2.Department of Nephrology,Changzheng Hospital,Navy Military Medical University and Kidney Disease Institute of PLA,Shanghai 200003,China )
4. HAO Xiaoping1(1.Department of Nephrology,Zhabei Central Hospital of Jing’an District,Shanghai 200070,China )
5. HU Xiaohua1(1.Department of Nephrology,Zhabei Central Hospital of Jing’an District,Shanghai 200070,China )
6. ZHANG Liming1(1.Department of Nephrology,Zhabei Central Hospital of Jing’an District,Shanghai 200070,China zlm198291@163.com)
ABSTRACT  Objective:To observe the expression of serum anti-phospholipase A2 receptor (PLA2R) antibodies in idiopathic membranous nephropathy (IMN),and also to explore the relationship between serum anti-PLA2R antibodies and immunotherapy.Methods:Serum anti-PLA2R antibodies and immunohistochemical staining were used to detect the expression levels of anti-PLA2R antibodies in the renal tissue of 60 IMN patients.According to the detection results of serum anti-PLA2R antibodies,they were divided into the positive group(44 cases) and the negative group (16 cases).The two groups were all treated with hormone combined with cyclophosphamide for a treatment course of 12 months.The changes in 24-h urinary protein,serum albumin,serum creatinine and glomerular filtration rate (eGFR) were observed before and after the treatment.And negative turning of serum anti-PLA2R antibodies before and after the treatment was also observed.Results:(1) Of the 60 patients with IMN,there were 44 patients with positive serum anti-PLA2R antibodies at baseline,with a positive rate of 73.3%.The expression of anti-PLA2R antibodies in the renal tissue of the patients with positive serum anti-PLA2R antibodies was also positive at baseline.(2) 24-h urinary protein and serum albumin recovery of the patients in the negative group were better than those in the positive group (P<0.05).(3)The total remission rates of the anti-PLA2R antibodies in the positive group and the negative group were 47.7% and 93.9% respectively after 6 months of the treatment,and total remission rates of the 2 groups were 56.8% and 100% respectively after 12 months of the treatment.Conclusion:Serum anti-PLA2R antibodies is a specific biomarker of IMN.Patients with positive serum anti-PLA2R antibodies show poor immunotherapy effect.Detection of serum anti-PLA2R antibodies in the IMN patients is helpful to judge the illness condition of the patient,and is of great importance for the choice of treatment strategy and monitoring of the disease.
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Please cite this article as:
TANG Qi1,WU Bibo1,LI Lin2,HAO Xiaoping1,HU Xiaohua1,ZHANG Liming1,. Relationship between serum anti-phospholipase A2 receptor antibodies and immunotherapy of the patients with idiopathic membranous nephropathy[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2019; 19(3): 180-184.
References:
1. Glassock R J.The pathogenesis of membranous nephropathy:evolution and revolution[J].Curr Opin Nephrol Hypertens,2012,21(3):235-242.
2. Hoxha E,Knei ler U,Stege G,et al.Enhanced expression of the M-type phospholipase A2 receptor in glomernli correlates with serum receptor antibodies in primary membranous nephropathy[J].Kidney Int,2012,82(7):797-804.
3. Beck L H Jr,Fervenza F C,Beck D M,et al.Rituximab-induced depletion of anti-PLA2R autoantibodies predicts response in membranous nephropathy[J].J Am Soc Nephrol,2011,22(8):1543-1550.
4. Svobodova B,Honsova E,Ronco P,et al.Kidney biopsy is a sensitive tool for retrospective diagnosis of PLA2R-related membranous nephropathy[J].Nephrol Dial Transplant,2013,28(7):1839-1844.
5. Anony. Chapter 7:Idiopathic membranous nephropathy[J].Kidney Int Suppl(2011),2012,2(2):186-197.
6. Beck L H Jr,Bonegio R G,Lambeau G,et al.M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy[J].N Engl J Med,2009,361(1):11-21.
7. QIN Weisong,Beck L H Jr,ZENG Caihong,et al. Anti-phospholipase A2 receptor antibody in membranous nephropathy[J].J Am Soc Nephrol,2011,22(6):1137-1143.
8. Bech A P,Hofstra J M,Brenchley P E,et al.Association of anti-PLA2R antibodies with outcomes after immunosuppressive therapy in idiopathic membranous nephropathy[J].Clin J Am Soc Nephrol,2014,9(8):1386-1392.
9. HAN Dannuo,CHEN Yipu,WANG Yanyan,et al.Detection of serum phospholipase A2 receptor antibodies and its clinical significance in patients with idiopathic membranous nephropathy[J].Chin J Pract Int Med,2015,35 (4):351-354.In Chinese with English abstract.
10. ZHOU Jun,LUO Sushan,PAN Haiyan.Association of the expression of anti-phospholipase A2 receptor antibody in serum with idiopathic membranous nephropathy[J].J Qingdao Univ(Med Sci),2018,54(4):439-442.In Chinese with English abstract.
11. SONG Dongxu,WANG Wutao,LIN Lu,et al.Clinical significance of autoantibodies against phospholipase A2 receptor in adult patients with idiopathic membranous nephropathy[J].Chin J Pract Int Med,2015,35(5):414-418.In Chinese with English abstract.
12. Skoberne A,Behnert A,Teng B,et al.Serum with phospholipase A2 receptor autoantibodies interferes with podocyte adhesion to collagen[J].Eur J Clin Invest,2014,44(8):753-765.
13. HUANG Jun,LI Jianwen,LIANG Ming,et al.Tacrolimus combined with prednisone for treatment of refractory idiopathic membranous nephropathy with persistent high serum anti phospholipase A2 receptor antibody titers[J].J Pract Med,2018,34(8):1355-1359.In Chinese with English abstract.
14. Segarra-Medrano A,Jatem-Escalante E,Carnicer-C ceres C, et al.Evolution of antibody titre against the M-type phospholipase A2 receptor and clinical response in idiopathic membranous nephropathy patients treated with tacrolimus[J].Nefrologia,2014,34(4):491-497.
15. ZHANG Lili,WANG Xiang,FAN Xiaoli,et al.Correlation between serum anti-PLA2R antibody and adult idiopathic membranous nephropathy[J].China J Mod Med,2016,26(9):44-48.In Chinese with English abstract.
16. Kanigicherla D,Gummadova J,McKenzie E A,et al.Anti-PLA2R antibodies measured by ELISA predict long-term outcome in a prevalent population of patients with idiopathic membranous nephropathy[J].Kidney Int,2013,83(5):940-948.
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