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Abstract
Pharmaceutical Care and Research: 2019; 19(3):188-191
DOI: 10.5428/pcar20190308
Study on median effective dose of ropivacaine combined with dexmedetomidine for ultrasound-guided interscalene brachial plexus block for arthroscopic shoulder surgery
1. ZHOU Yan(Department of Anesthesiology,Changhai Hospital,Navy Military Medical University,Shanghai 200433,China 13564155655@163.com)
2. FAN Lihua(Department of Anesthesiology,Changhai Hospital,Navy Military Medical University,Shanghai 200433,China )
3. ZHANG Lijun(Department of Anesthesiology,Changhai Hospital,Navy Military Medical University,Shanghai 200433,China )
4. DENG Yu(Department of Anesthesiology,Changhai Hospital,Navy Military Medical University,Shanghai 200433,China )
5. BU Lan(Department of Anesthesiology,Changhai Hospital,Navy Military Medical University,Shanghai 200433,China )
6. LIU Zheng(Department of Anesthesiology,Changhai Hospital,Navy Military Medical University,Shanghai 200433,China liuzheng19821007@icloud.com)
ABSTRACT  Objective: To investigate the median effective dose(ED50) of 0.375% ropivacaine combined with dexmedetomidine for ultrasound-guided interscalene brachial plexus block(ISBPB) of the patients undergoing arthroscopic shoulder surgery.Methods: Thirty patients who were classified as grade Ⅰ or Ⅱ according to American Society of Anesthesiologists(ASA) and underwent shoulder arthroscopic surgery were enrolled for the study regardless of gender.The patients started to have the pumping of dexmedetomidine (0.5 μg·kg-1·h-1) for ultrasound-guided interscalene brachial plexus block in arthroscopic shoulder surgery when they were admitted into the operating room.The starting dose of 0.375% ropivacaine was 100 mg for the first patient and the ratio between adjacent patients’ doses was 1.2.The ED50 and 95% confidence interval of ropivacaine was calculated by up-and-down methodology.The anesthetic effect and adverse drug reactions(ADRs) of the patients were observed closely.Results: The ED50 of 0.375% ropivacaine combined with dexmedetomidine for ultrasound-guided interscalene brachial plexus block for arthroscopic shoulder surgery was 19 ml and 95% confidence interval was 17.5-21.5 ml.There was one case of Horner syndrome and one case of hypotensive bradycardia event during surgery.Conclusion: Ropivacaine combined with dexmedetomidine in ultrasound-guided brachial plexus block could reduce the dosage of ropivacaine in patients undergoing shoulder arthroscopic surgery,with good anesthetic effect and without severe ADRs.
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Please cite this article as:
ZHOU Yan,FAN Lihua,ZHANG Lijun,DENG Yu,BU Lan,LIU Zheng,. Study on median effective dose of ropivacaine combined with dexmedetomidine for ultrasound-guided interscalene brachial plexus block for arthroscopic shoulder surgery[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2019; 19(3): 188-191.
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