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Abstract
Pharmaceutical Care and Research: 2019; 19(3):196-200
DOI: 10.5428/pcar20190310
Preparation of compound neomycin sulfate thermosensitive gel and observation of its therapeutic effect
1. SUN Shuyan1(1.Department of Stomatology,Changhai Hospital,Navy Military Medical University,Shanghai 200433,China sunshuyan21@163.com)
2. GU Yongwei2(2.Department of Pharmacy,Changhai Hospital,Navy Military Medical University,Shanghai 200433,China )
3. YANG Meng3(3.Department of Pharmacy, Shanghai Ninth People’s Hospital Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 200011,China )
4. LIU Jiyong2(2.Department of Pharmacy,Changhai Hospital,Navy Military Medical University,Shanghai 200433,China )
5. TANG Zhen1(1.Department of Stomatology,Changhai Hospital,Navy Military Medical University,Shanghai 200433,China tangzhen1999@aliyun.com)
ABSTRACT  Objective: To prepare compound neomycin sulfate thermosensitive gel and also to study its therapeutic effect on oral ulcer.Methods: The effective components of the original compound neomycin sulfate oral ulcer film were retained and the thermosensitive gel preparation technology was used to develop the thermosensitive gel.Forty-eight rats with traumatic oral ulcer induced by 50% glacial acetic acid were randomly divided into model group,blank gel group,control group,high, medium and low frequency medication of compound neomycin sulfate thermosensitive gel groups,each group consisting of 8 rats.The seriousness of oral ulcer was observed and the changes in ulcer sizes of the rats in all the groups were determined before and after the medication.Tissue sections from ulcers of the rats were prepared.Pathological changes in the ulcer tissues were observed after HE staining.Results:The formulation of the compound neomycin sulfate thermosensitive gel was appropriate.Compared with that of the model group, the ulcer sizes of the rats in the high, medium and low frequency medication groups at days 2,3,4 after the medication reduced significantly(P<0.01).Furthermore,there was a certain dosage-dependent relationship between them.Four days after the medication, the ulcer surface of the rats in each medication group healed completely, with smooth ulcer surface and light inflammatory response.The pathological observation results showed that the epithelium of the rats in the control group, the high and the medium frequency medication groups were intact,healed well,and only a few inflammatory cells infiltrated.Conclusion: The formulation of compound neomycin sulfate thermosensitive gel is reasonable.The preparation methods are feasible,and the gel could promote the healing of traumatic oral ulcer induced by glacial acetic acid.
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Please cite this article as:
SUN Shuyan1,GU Yongwei2,YANG Meng3,LIU Jiyong2,TANG Zhen1,. Preparation of compound neomycin sulfate thermosensitive gel and observation of its therapeutic effect[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2019; 19(3): 196-200.
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