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Abstract
Pharmaceutical Care and Research: 2019; 19(3):201-204
DOI: 10.5428/pcar20190311
Study on the quality standards of Fufangbohefensuan tincture
1. LI Jingxian(Department of Pharmacy,Changzheng Hospital, Navy Military Medical University,Shanghai 200003,China beckylee917@126.com)
2. CHEN Wansheng(Department of Pharmacy,Changzheng Hospital, Navy Military Medical University,Shanghai 200003,China chenws126@126.com)
ABSTRACT  Objective: To establish the quality standards of Fufangbohefensuan tincture.Methods:Menthol in Fufangbohefensuan tincture was identified by thin layer chromatography(TLC) method.The contents of ethanol and boric acid in Fufangbohefensuan tincture were determined by distillation and acid-base titration,respectively.The contents of phenol and dexamethasone sodium phosphate were determined by HPLC method with Agilent Zorbax SB C18 column (250 mm×4.6 nm,5 μm ) as the chromatographic column.The mobile phase consisted of 0.05 mol/L sodium acetate solution(the pH value was adjusted to 4.0 with glacial acetic acid)-methanol (40∶60).The detection wavelength was 242 nm and the injection volume was 20 μl.The flow rate was 1.0 ml/min and the column temperature was 30 ℃.Results:The spots were clear,the specificity was good and the negative control had no interference in TLC detection.The contents of phenol in the sample ranged from 42% to 52%.Acid-base titration method had sharp end point,high accuracy and was easy to operate.The contents of phenol and dexamethasone sodium phosphate in the ranges of 502-1506 and 5.61-89.63 μg/ml showed a good linear relationship (r=0.999 9).The average recovery rates of phenol and dexamethasone sodium phosphate were (99.4±0.36)% and (100.1±0.29)%(n=3).Conclusion: The established method is simple and reliable,and could be used for quality control of Fufangbohefensuan tincture.
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Please cite this article as:
LI Jingxian,CHEN Wansheng,. Study on the quality standards of Fufangbohefensuan tincture[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2019; 19(3): 201-204.
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