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Abstract
Pharmaceutical Care and Research: 2019; 19(3):213-215
DOI: 10.5428/pcar20190314
Influence of risperidone combined with Daying tablets on social function in treatment of schizophrenia patients
1. XIANG Wei(Department of Psychiatry,Shanghai Mental Health Center Affiliated to School of Medicine,Shanghai Jiaotong University, Shanghai 201108,China 453505301@qq.com)
2. ZHU Liping(Department of Psychiatry,Shanghai Mental Health Center Affiliated to School of Medicine,Shanghai Jiaotong University, Shanghai 201108,China zlpjsk@126.com)
3. CHEN Yan(Department of Psychiatry,Shanghai Mental Health Center Affiliated to School of Medicine,Shanghai Jiaotong University, Shanghai 201108,China chenyan56@sina.com)
4. ZHANG Jianming(Department of Psychiatry,Shanghai Mental Health Center Affiliated to School of Medicine,Shanghai Jiaotong University, Shanghai 201108,China )
5. LONG Bin(Department of Psychiatry,Shanghai Mental Health Center Affiliated to School of Medicine,Shanghai Jiaotong University, Shanghai 201108,China )
ABSTRACT  Objective: To investigate the influence of risperidone combined with Daying tablets on social function in treatment of schizophrenia patients.Methods: Totally,117 schizophrenia patients were divided into the observation group (n=56) and the control group (n=61) by simple randomization method.The patients in the observation group were treated with risperidone combined with Daying tablets.The patients in the control group were treated with risperidone combined with placebo tablets.The course of treatment was 12 weeks.Clinical efficacy was evaluated by positive and negative syndrome scale (PANSS) and personal and social perormance scale(PSP).Results: 12 weeks after treatment, the PANSS total scores, positive/negative, general psychopathology symptom scale scores of the patients both in the observation group and the control group were all lower than those before treatment (P<0.01).The total effective rate of PANSS in the observation group was significantly higher than that in the control group(P<0.01).12 weeks after treatment, PSP scores in the observation group and the control group were all higher than those before treatment, and PSP scores in the observation group were also obviously higher than those in the control group(P<0.05).After treatment, the difference of PSP scores in the observation group was positively correlated with the difference of PANSS total scores and its negative, general psychopathology symptom scale scores (P<0.05); the difference of PSP score in the control group was also positive correlated with the difference of PANSS total scores and positive scores (P<0.05).Conclusion: Risperidone combined with Daying tablets could significantly improve social function of schizophrenia patients,and social function recovery was positively correlated with the improvement of mental symptoms.
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Please cite this article as:
XIANG Wei,ZHU Liping,CHEN Yan,ZHANG Jianming,LONG Bin,. Influence of risperidone combined with Daying tablets on social function in treatment of schizophrenia patients[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2019; 19(3): 213-215.
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