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Abstract
Pharmaceutical Care and Research: 2019; 19(3):226-229
DOI: 10.5428/pcar20190317
One case of intracranial administration of tigecycline for treatment of extensively drug-resistant Acinetobacter baumannii intracranial infection
1. HUANG Rongbin1(Department of Pharmacy, First People’s Hospital of Xiangtan City,Hunan Province,Hunan Xiangtan 411101,China 675283508@qq.com)
2. GU Tiebo(Department of Pharmacy, First People’s Hospital of Xiangtan City,Hunan Province,Hunan Xiangtan 411101,China huang_lcyx168@163.com)
ABSTRACT  Objective: To explore the rationality of off-label intracranial administration of tigecycline, so as to provide reference for clinical treatment of the disease.Methods: In the treatment of the patient with intracranial infection caused by extensively drug-resistant Acinetobacter baumannii, the physicians and pharmacists worked closely together in the analysis and treatment of the case.In accordance with the literature obtained, intravenous infusion and intracranial (ventricular/intrathecal) injection of tigecycline was applied and pharmaceutical care was performed in the whole process of the treatment.Results:Intracranial infection of the patient was controlled, patient consciousness gradually recovered and there were no adverse drug reactions involving nervous system.Three-month medical follow-ups indicated that the general conditions of the patient were good, consciousness and limb function gradually improved.Conclusion: Intravenous infusion combined with intracranial injection of tigecycline might be the right choice for the treatment of intracranial infections caused by drug-resistant bacteria.
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Please cite this article as:
HUANG Rongbin1,GU Tiebo,. One case of intracranial administration of tigecycline for treatment of extensively drug-resistant Acinetobacter baumannii intracranial infection[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2019; 19(3): 226-229.
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