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Abstract
Pharmaceutical Care and Research: 2019; 19(4):244-249
DOI: 10.5428/pcar20190402
Optimization of formulation and preparation technology of lutein liposomes by central composite design-response surface method
1. LI Chuanling1(1.Department of Pharmacy,Hongkou Branch,Changhai Hospital,Navy Military Medical University,Shanghai 200434,China wylcl001@163.com)
2. 2(2.Teaching and Research Section of Pharmaceutics,School of Pharmacy,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China )
3. SHI Xiaoqing1(1.Department of Pharmacy,Hongkou Branch,Changhai Hospital,Navy Military Medical University,Shanghai 200434,China )
4. 2(2.Teaching and Research Section of Pharmaceutics,School of Pharmacy,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China )
5. HUANG Yueying1(1.Department of Pharmacy,Hongkou Branch,Changhai Hospital,Navy Military Medical University,Shanghai 200434,China )
6. BIAN Jun1(1.Department of Pharmacy,Hongkou Branch,Changhai Hospital,Navy Military Medical University,Shanghai 200434,China bianjun411@163.com)
ABSTRACT  Objective:To optimize the formulation and preparation technology of lutein liposomes by central composite design-response surface method.Methods:On the basis of single factor test,entrapment efficiency,particle size and leakage rate were selected as independent variables,lutein dosage,mass ratio of soybean lecithin to cholesterol,rotary steaming temperature were selected as dependent variables.The results were fitted by design-response surface methodology.The formulation was optimized by three-dimensional response surface and contour lines graphs.The predictive data were validated.Results:The optimal formulation and preparation technology were as follows:the lutein dosage was 5.34 mg,mass ratio of soybean lecithin to cholesterol was 14.35∶1,rotary steaming temperature was 32.9 ℃.Under the optimal conditions,the average entrapment efficiency of three batches of lutein liposomes was (87.49±0.33)%,the particle size was (68.52±0.21) nm and the leakage rate was (14.54±0.50)%.Conclusion: The preparation technology of lutein liposomes by central composite design-response surface method is simple,stable and feasible,and is suitable for the preparation of lutein liposomes.
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Please cite this article as:
LI Chuanling1,2,SHI Xiaoqing1,2,HUANG Yueying1,BIAN Jun1,. Optimization of formulation and preparation technology of lutein liposomes by central composite design-response surface method[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2019; 19(4): 244-249.
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