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Pharmaceutical Care and Research: 2019; 19(4):255-258,270
DOI: 10.5428/pcar20190405
Efficacy comparison of Tianhe polyisobutylene type gutong plaster and common gutong plaster in treatment of knee osteoarthritis
1. WU Yang1(1.Department of Orthopaedics,Beijing Hepingli Hospital,Beijing 100013,China
2. SUN Tong2(2.Department of Orthopaedics,Beijing Anzhen Hospital,Beijing 100029,China )
3. LI Xiaodong3(3.Department of Orthopaedics,Tianjin Third Central Hospital,Tianjin 300170,China )
4. LIU Zhongwei4(4.Department of Traditional Chinese Medicine,Tianjin Public Security Hospital,Tianjin 300070,China )
ABSTRACT  Objective:To compare the efficacy and safety of Tianhe polyisobutylene (PIB) type gutong plaster and common gutong plaster in the treatment of knee osteoarthritis.Methods:A total of 403 patients with knee osteoarthritis in 4 hospitals were enzolled in the study,and were divided into the experimental group (n=199) and the control group (n=204),according to the treatment sites.The patients in the experimental group were treated with external application of Tianhe PIB type gutong plaster,while the patients in the control group were treated with external application of Tianhe common gutong plaster,once a day for 7 successive days.Changes in the visual analogue scores (VAS) and Lysholm knee function scores before and after treatment were compared between the patients in the 2 groups,and the rate of adverse drug reactions (ADRs) during medication were recorded as well.Results: The VAS scores and Lysholm scores of the patients in the 2 groups were all significantly improved after treatment (P<0.05).Compared with the control group,the experimental group was significantly better in pain control,improvement in claudication,instability,pain,swelling,stair climbing and squatting (P<0.05).Meanwhile,the rate of ADRs of the experimental group was obviously lower than that of the control group (2.01% vs 13.73%,P<0.05).Conclusion: Tianhe PIB type gutong plaster could achieve significant efficacy in the treatment of knee osteoarthritis.In addition to pain control,it could improve joint function,with lower rate of ADRs.For this reason,it is worth further clinical extension.
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Please cite this article as:
WU Yang1,SUN Tong2,LI Xiaodong3,LIU Zhongwei4,. Efficacy comparison of Tianhe polyisobutylene type gutong plaster and common gutong plaster in treatment of knee osteoarthritis[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2019; 19(4): 255-258,270.
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