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Abstract
Pharmaceutical Care and Research: 2019; 19(4):288-291
DOI: 10.5428/pcar20190413
Influence of pharmaceutical intervention on drug cost and clinical prognosis of infected patients in intensive care unit
1. WANG Haitao1(1.Department of Pharmacy,the Second Hospital Affiliated to Xi’an Jiaotong University,Xi’an 710004,China acmilan781114@yahoo.com)
2. WANG Na1(1.Department of Pharmacy,the Second Hospital Affiliated to Xi’an Jiaotong University,Xi’an 710004,China )
3. LIU Na1(1.Department of Pharmacy,the Second Hospital Affiliated to Xi’an Jiaotong University,Xi’an 710004,China )
4. YU Jingjie1(1.Department of Pharmacy,the Second Hospital Affiliated to Xi’an Jiaotong University,Xi’an 710004,China )
5. WANG Chunya2(2.Intensive Care Unit,the Second Hospital Affiliated to Xi’an Jiaotong University,Xi’an 710004,China )
6. ZHAO Yujie2(2.Intensive Care Unit,the Second Hospital Affiliated to Xi’an Jiaotong University,Xi’an 710004,China )
ABSTRACT  Objective: To analyze pharmaceutical intervention by clinical pharmacists on patients in the intensive care unit(ICU) of the Second Hospital Affiliated to Xi’an Jiaotong University,and evaluate the influence of pharmaceutical intervention on drug cost and clinical prognosis.Methods:Pharmaceutical intervention by clinical pharmacists on infected patients in ICU mainly includes three types,the intervention based on clinical efficacy and nephrotoxicity,the intervention based on medical cost and other interventions.Specific interventions include replacement with appropriate antibacterials,abandoning of unnecessary antibacterials,abandoning of two or more drugs with nephrotoxicity,adjustment of medication frequency or dosages of the drugs,combined use of antibiotics,changes of administration routes,etc.402 infected patients in the ICU of the hospital were divided into the pharmaceutical intervention group(n=190) and the non-pharmaceutical intervention group(n=212).The drug cost and prognosis of infected patients were compared between the two groups.Results: The daily average drug cost of the patients in the pharmaceutical intervention group was significantly lower than that of the patients in the non-pharmaceutical intervention group [(2 220.99±734.45) RMB/d vs (2 455.27±811.24) RMB/d,P=0.003],the average hospitalization duration was even shorter [(7.81±4.00) d vs (8.73±4.08) d,P=0.022],and the rate of nephrotoxic adverse drug reactions(ADRs) was significantly lower [5.79%(11/190) vs 12.73%(27/212),P=0.019].Conclusion: Pharmaceutical intervention by clinical pharmacists on the infected patients in ICU could reduce drug cost,shorten hospitalization duration,lower the rate of nephrotoxic ADRs,and is of important clinical significance.
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Please cite this article as:
WANG Haitao1,WANG Na1,LIU Na1,YU Jingjie1,WANG Chunya2,ZHAO Yujie2,. Influence of pharmaceutical intervention on drug cost and clinical prognosis of infected patients in intensive care unit[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2019; 19(4): 288-291.
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