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Abstract
Pharmaceutical Care and Research: 2019; 19(4):309-313
DOI: 10.5428/pcar20190418
Investigation and category management of off-label drug use in the outpatient department prescriptions of Maternity and Child Health Care Center of Putuo District of Shanghai
1. LIN Tao(Department of Pharmacy,Maternity and Child Health Care Center of Putuo District of Shanghai,Shanghai 200062,China lintao199308@163.com)
2. LIU Jingjing(Department of Pharmacy,Maternity and Child Health Care Center of Putuo District of Shanghai,Shanghai 200062,China jingjing_207@sina.com)
ABSTRACT  Objective: To investigate the situation of off-label drug use in the Outpatient Department, Maternity and Child Health Care Center of Putuo District of Shanghai, so as to provide reference for promotion of clinical rational use of drugs. Methods: A total of 4849 prescriptions prescribed on the 5th, 15th and 25th of each month during the time span from July to December, 2017 were selected for the study. Off-label drug use was identified in accordance with the inserted drug directions, the information concerning prescriptions was recorded and evidence levels were graded for the drugs involved (grade Ⅰ-Ⅴ or without evidence). Results: The rate of off-label drug use was 9.2%, involving 23 drug categories, with a total of 32 off-label drug use, mainly displaying in off-indication drug use (88.7%). The top 3 drugs involved in off-label drug use were the complex packing estradiol tablets/estradiol and dydrogesterone tablets, mifepristone tablets and tamoxifen citrate tablets. Most off-label drug use had the support of medical evidences, in which there were 28 with Ⅰ to Ⅱ grades, 2 with Ⅲ grade and one with Ⅴ grade. Conclusion: There was off-label drug use in the outpatient of the Center. An off-label drug use management system should be established by the department of pharmacy on the bases of patient knowledge and consent and evidence-based medicine, so as to avoid medical risks and ensure safety of clinical medication.
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Please cite this article as:
LIN Tao,LIU Jingjing,. Investigation and category management of off-label drug use in the outpatient department prescriptions of Maternity and Child Health Care Center of Putuo District of Shanghai[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2019; 19(4): 309-313.
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